Posted by SLS on December 11, 2012, at 7:22:54
In reply to How do I lower pro-inflammatory cytokines?, posted by Trotter on December 11, 2012, at 2:55:57
> Recently I have been reading how inflammation and pro-inflammatory cytokines can cause depression. I am looking at way to reduce PICs. I have read that reducing omega-6 fats while increasing omega-3s is a good idea. Turmeric/curcumin and ginger may also help. Anyone got any other ideas?
Check out minocycline. Minocycline is used as an antibiotic, but it has other several properties, some of which reduce inflammation in the brain.
http://www.ncbi.nlm.nih.gov/pubmed/22486246
200 mg/day is often chosen in clinical studies.
http://clinicaltrials.gov/show/NCT01403662
http://clinicaltrials.gov/show/NCT01514422
"Several lines of evidence implicate the inflammatory system as consequential and causative to mood disorder. Bipolar disorder is marked by alterations in inflammatory cytokines (e.g. TNF-alpha, IL-6). Moreover, pro-inflammatory activation in both healthy and medically ill individuals is associated with disturbances in affective, cognitive, and somatic function.
The clinical use of cytokine-based therapy has been demonstrated to induce and/or intensify affective symptomatology in non-psychiatric medical patients. Conventional pharmacological treatments (e.g. lithium) for bipolar disorder affects the production of pro-inflammatory cytokines as well as their gene expression. The encompassing aim of the study herein is to develop a novel treatment for bipolar depression based on a model of disease pathophysiology. Minocycline is a semisynthetic second-generation tetracycline, which exerts anti-inflammatory effects that are distinct from its antimicrobial properties.
Minocycline is a potent inhibitor of microglial activation and decreases expression of pro-inflammatory cytokines, chemokines and their receptors and suppresses the activity of matrix metalloproteinases. Minocycline has been shown to exert antidepressant-like properties in preclinical studies. Rats treated with minocycline monotherapy as well as combination treatment with an antidepressant (desipramine) exhibited significantly improved performance on the forced swim test. Adjunctive minocycline has been shown to be efficacious for the treatment of schizophrenia in a double-blind, randomized, placebo-controlled study. Subjects receiving minocycline exhibited a significant improvement in negative symptoms as well as global improvement as measured with the Clinical Global Impression (CGI). Significant improvement was also noted on measures of executive function, including executive function composite score, spatial recognition memory, cognitive planning, and intradimensional/extradimensional set shifting."
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I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1032810
URL: http://www.dr-bob.org/babble/20121130/msgs/1032822.html