Posted by linkadge on February 24, 2015, at 19:29:54
In reply to Re: Got genetic results., posted by Bill82 on February 24, 2015, at 17:45:01
Hmm. The results are interesting. However, I am wondering to the weight of the individual gene results also considering the weight of unknown genes which may trump.
As for the 5-ht2c thing, if somebody had an overactive 5-ht2c receptor, it is still possible for too much of a 5-ht2c antagonist to shift one into a state of under activity.
I think that I probably have an overactive 5-ht2c (or underactive cannabinoid system). I am 6 feet 2 inches and about 125 pounds. I can't gain much of anything. The right amount of remeron works for me, but too much and I get rage / anger issues too. Mice lacking the 5-ht2c receptor tend to be overaggressive, so the fact that 2c antagonists induce anger is no surprising.
If the study says normal ANK3 but bad CANAC, I would tend to take a L type calcium antagonist rather than a sodium channel blocker. Verapamil would be better than say tegretol or Depakote as these hit other targets. Deregulation in calcium homeostasis can induce all sorts of mood irregularities. I think that the ANK3 is more liked to classic bipolar whereas the CANAC is lined to affective instability, and interpersonal sensitivity / anxiety traits.
I have often thought (although I have no proof) that I have a deregulation in 5-ht2c and some sort of ion channel. I also think I have some dopamine or GSK-3 circadian rhythm issues.
Of course, there are a lot of unresearched or under researched areas such as opioid, cannabinoid, immune system, epigenetic, hormonal and gabaergic etc....
I'm hoping that, in my lifetime I can really nail down the key gene or gene's which affect my illness. But, this is all in its infancy.
Linkadge
poster:linkadge
thread:1077064
URL: http://www.dr-bob.org/babble/20150223/msgs/1077087.html