Psycho-Babble Medication Thread 1082582

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Buprenorphine trial - dose and risk of withdrawal?

Posted by Uncouth on September 17, 2015, at 11:33:00

Hi,

I'm planning on trying low dose buprenorphine for my refractory bipolar depression, anhedonia, and amotivation.

I've gotten ahold of 0.2mg buprenorphine. I have never been addicted to any opiates, and have only taken hydrocodone after surgery. I'm interested in bupe due to its kappa opioid antagonistic effects, but concerned that even such a low dose and short term trial might cause severe withdrawal.

Does anyone have experience trying bupe at such a low dose, and know whether even a brief trial without dose escalation would mean I end up hooked? I'm thinking 0.2mg 2-3x a day, which seems to be what people using bupe for depression start at.

Thanks,
Uncouth

 

Re: Buprenorphine trial - dose and risk of withdrawal?

Posted by baseball55 on September 17, 2015, at 18:51:31

In reply to Buprenorphine trial - dose and risk of withdrawal?, posted by Uncouth on September 17, 2015, at 11:33:00

An addiction p-doc I know believes buprenorphine is turning out to be like methadone - almost impossible to get off of. He is a licensed prescriber and does not believe in maintenance therapy for opiod addicts. That said, I think you should not use this addictive drug without the supervision of an experienced prescriber.

> Hi,
>
> I'm planning on trying low dose buprenorphine for my refractory bipolar depression, anhedonia, and amotivation.
>
> I've gotten ahold of 0.2mg buprenorphine. I have never been addicted to any opiates, and have only taken hydrocodone after surgery. I'm interested in bupe due to its kappa opioid antagonistic effects, but concerned that even such a low dose and short term trial might cause severe withdrawal.
>
> Does anyone have experience trying bupe at such a low dose, and know whether even a brief trial without dose escalation would mean I end up hooked? I'm thinking 0.2mg 2-3x a day, which seems to be what people using bupe for depression start at.
>
> Thanks,
> Uncouth

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