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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by ssro on May 10, 2014, at 19:25:07
Hi,
I was prescribed 200mg of daily Amisulpride over the course of 6 months, for depression. Also, 20mg of Fluoxetine, though this was discontinued 2 months ago. The mental impairments were starting to become very noticeable, so I tapered off and took my last dose of Amisulpride about 2-3 weeks ago. I'm happy to report that my depression is gone.
Now I must admit to being a casual user of recreational drugs, though none were consumed during his treatment! Trial and error have convinced me that I literally do not or hardly respond anymore to dopaminergic/serotonergic substances - almost 3 weeks after discontinuation of Amisulpride! I'm not so much concerned with the loss of my hedonistic vice. I rather fear that this could be one symptom of deep underlying changes to my brain which would affect me in my everyday life. Now I even dream of having had a chemical lobotomy!
Can someone reassure him that this is not unheard of and things will revert back to normal? Talking to my former pdoc is not an option. Numerous bad experiences have made me lose all trust (in psychiatry itself).
Thanks.
Posted by ssro on May 10, 2014, at 19:27:23
Hi,
I was prescribed 200mg of daily Amisulpride over the course of 6 months, for depression. Also, 20mg of Fluoxetine, though this was discontinued 2 months ago. The mental impairments were starting to become very noticeable, so I tapered off and took my last dose of Amisulpride about 2-3 weeks ago. I'm happy to report that my depression is gone.
Now I must admit to being a casual user of recreational drugs, though none were consumed during his treatment! Trial and error have convinced me that I literally do not or hardly respond anymore to dopaminergic/serotonergic substances - almost 3 weeks after discontinuation of Amisulpride! I'm not so much concerned with the loss of my hedonistic vice. I rather fear that this could be one symptom of deep underlying changes to my brain which would affect me in my everyday life. Now I even dream of having had a chemical lobotomy!
Can someone reassure me that this is not unheard of and things will revert back to normal? Talking to my former pdoc is not an option. Numerous bad experiences have made me lose all trust (in psychiatry itself).
Thanks.
Posted by Christ_empowered on May 11, 2014, at 2:03:39
In reply to Has Amisulpride fried my synapses?, posted by ssro on May 10, 2014, at 19:25:07
I think you'll be OK. Just don't take antipsychotics again unless you're agitated or psychotic.the "chemical lobotomy" requires high doses of neuroleptics for a long time. Adding stimulants or antidepressants can make it happen faster, I think, but...still...no. Your brain is not fried.
The only way I'd personally think you could have serious problems after such short term, relatively low dose exposure would be if you have tardive dyskinesia (sometimes happens after short term exposure) or withdrawal dyskinesia (happens, like the name suggests, after tapering off the antipsychotic).
Although dyskinesia is a movement disorder, it may also be a "dementing disorder," in that its associated with cognitive dulling.
Blah blah blah...I think you're fine, honestly. Psych drugs are potentially harmful, but short term exposure at controlled doses is not a huge deal (though still far from ideal, obviously).
Good luck!
Posted by Jeroen on May 11, 2014, at 9:00:02
In reply to Re: Has Amisulpride fried my synapses?, posted by Christ_empowered on May 11, 2014, at 2:03:39
Hi, with all due respect, i feel the same how you feel how psychiatry has treathed you, i also feel i have "what you have now"
Posted by poser938 on May 11, 2014, at 14:11:24
In reply to Has Amisulpride fried my synapses?, posted by ssro on May 10, 2014, at 19:25:07
I wouldn't count 6 months as being short term.
taking dopaminergic meds over about 6 weeks is all it took for me to completely lose my hedonic capacity.
I also no longer respond to any meds.though, the only thing that ever came close to giving me back my normal brain function was Periactin.
it seemed to be great for getting my dopamine system up and running again. though it eventually stopped working.
my sense of wellbeing, joy and motivation all came back while I was taking it.
Posted by ssro on May 11, 2014, at 18:42:17
In reply to Re: Has Amisulpride fried my synapses?, posted by poser938 on May 11, 2014, at 14:11:24
> I wouldn't count 6 months as being short term.
>
> taking dopaminergic meds over about 6 weeks is all it took for me to completely lose my hedonic capacity.
> I also no longer respond to any meds.
>
> though, the only thing that ever came close to giving me back my normal brain function was Periactin.
>
> it seemed to be great for getting my dopamine system up and running again. though it eventually stopped working.
> my sense of wellbeing, joy and motivation all came back while I was taking it.
I'm sad to hear that you have the same problems. My anhedonia was already bad since before the treatment, but taking certain meds on rare occasions would give me a sense of what it feels like to be normal. Now that's gone too :(. **** psychiatry. Most doctors don't mean no harm*, they're clueless, but the system itself is backwards and rotten!*Actually, mine almost killed me when she didn't account for amisulpride's biphasic effects (dopaminergic below 200mg, neuroleptic above). The sudden increase from 200 to 400 triggerd acute FULL BODY dyskinesia. Worst pain in my life, and I could hardly breathe till the hospital staff injected me with an antagonist. That was the last straw for me!
This is the end of the thread.
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