Posted by SLS on October 1, 2006, at 20:28:29
In reply to Re: Returning to antidepressants? Above for, posted by musky on October 1, 2006, at 11:58:22
> > >First of all, diabetes and high blood pressure are KNOWN diseases.. they have blood tests SPECIFICALLY for measuring levels of blood glucose and blood pressure. The drugs developed for these conditions are SPECIFIC and then shown to work by further measuring these levels.
Ok.
> Antidepressents are NOT specific and affect MANY downstream pathways in the brain...
How do you know whether they are upstream or downstream? Scientists haven't decided that yet.
Insulin is not treating the disease. The disease in in the pancreas. As you say, it is affecting things downstream.
If it works, it works. Right?
So, anyway...
> They "think" that it affects serontonin but not definite on how this occurs.
I don't know who you think "they" are. If you take a look at the more recent work on depression, you will find that there are many different areas of investigation. I don't think that most scientists conceptualize depression as being the result of a simple reduction in "serotonin levels". That is an old and primordial way of thinking. However, it is still a commonly used explanation of depression for the lay public. Nothing more.
> There is no specific serontonin test(that is a regular blood test, like one for blood sugar).
Well, actually, blood platelets contain neurotransmitter receptors and transporters. The binding of some of these receptors vary in depression and some anxiety disorders. Although there is no consensus as to which receptors yield the most consistent associations, I don't doubt that a test might be developed soon. Some are even experimenting with blood platelet characteristics in order to predict treatment response. So, yes, blood test may be possible.
A blood test has been in existence for over 20 years. Known as the dexamethasone suppression test (DST), it involves the measurement of cortisol in response to steroid challenge. I had it done in 1982 and I tested positive. This test probably fell out of favor because it did not detect all types of depression. It is unfortunate that it was not pursued as a test for treatment choice. My guess is that people who test positive to the DST are more apt to respond to certain drugs - TCA, MAOIs, and Effexor perhaps.
> So how can they "measure " the effectiveness of the drug???
You ask the patient how they are feeling.
- Scott
poster:SLS
thread:689668
URL: http://www.dr-bob.org/babble/wdrawl/20060809/msgs/690935.html