Posted by SLS on April 26, 2011, at 18:44:27
In reply to Re: Viibryd/Vilazodone PI and efficacy..., posted by mtdewcmu on April 26, 2011, at 12:02:57
> I thought that 5-ht1a was the main receptor that you wanted to stimulate in depression. Viibryd is reported to be a partial agonist at 5-ht1a, which would tend to put a ceiling on 5-ht1a effects. However, there should be no ceiling on effects at 5-ht2a, so it might make an interesting psychedelic <g>.
If I remember correctly, the 5-HT1a receptors that Viibryd partially agonizes are somato-dendritic autoreceptors. The greater the stimulation of 5-HTta autoreceptors, the greater the inhibition of serotonin synthesis and release. There are postsynaptic 5-HT1a receptors, too. They are localized in the hippocampus. When these receptors are stimulated, explicit memory function can suffer. Blockade of these receptors can improve explicit memory. Tandospirone, a 5-HT1a agonist, is sometimes used to study these receptors.
I wish there were a "Psychopharmacology For Dummies" book with easy-to-interpret charts to keep track of all of this.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:983120
URL: http://www.dr-bob.org/babble/20110418/msgs/983842.html