Posted by bulldog2 on April 10, 2010, at 13:20:11
In reply to Re: How Is Clomipramine Different From An SSRI?, posted by linkadge on April 10, 2010, at 12:46:11
> Clomipramine's metabolite is preferentially a NRI. So overall, clomipramine has some potent noradrenergic activity.
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> Other mechanisms with potential theraputic effect are:
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> - opioid receptor activity (like other TCA's)
> - 5-ht2 receptor antagonism (AD augmentation)
> - 5-ht7 antagonism (augments hippocampal serotonin levels)
> - antihistamine action (anxiety)
> - anticholingeric function (anxiety / depression)
> - interaction with receptor channnels (anxiety, and affect stabilization)
>
> etc.
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> Linkadge
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>Thank. Excellent info. Right now my p-doc and I and considering your recent med trial. He likes it. I have climbed slowly on elavil to 30 mg with virtually no problems and I like the way it feels. At 30 really doesn't feel that dirty.Probably will add in the stimulant soon.
However it seems as if clomipramine might be more powerful than elavil. I was wondering if clomipramine might be more powerful than the other tcas on a mg per mg basis. I've heard of it's terrible sides but I was wondering if it might be more tolerable if one goes up slowly and has a goal of a low dose. I generally do not require high doses on these meds.
For purposes of pain control does any tca have more opioid activity than the others?
poster:bulldog2
thread:942961
URL: http://www.dr-bob.org/babble/20100406/msgs/942979.html