Re: How Is Clomipramine Different From An SSRI?

Posted by linkadge on April 10, 2010, at 12:46:11

In reply to How Is Clomipramine Different From An SSRI?, posted by bulldog2 on April 10, 2010, at 12:24:22

Clomipramine's metabolite is preferentially a NRI. So overall, clomipramine has some potent noradrenergic activity.
Other mechanisms with potential theraputic effect are:
- opioid receptor activity (like other TCA's)
- 5-ht2 receptor antagonism (AD augmentation)
- 5-ht7 antagonism (augments hippocampal serotonin levels)
- antihistamine action (anxiety)
- anticholingeric function (anxiety / depression)
- interaction with receptor channnels (anxiety, and affect stabilization)
etc.
Linkadge

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How Is Clomipramine Different From An SSRI? bulldog2 4/10/10
Re: How Is Clomipramine Different From An SSRI? linkadge 4/10/10
Re: How Is Clomipramine Different From An SSRI? Phillipa 4/10/10
Re: How Is Clomipramine Different From An SSRI? bulldog2 4/10/10
Re: How Is Clomipramine Different From An SSRI? manic666 4/10/10
Re: How Is Clomipramine Different From An SSRI? » manic666 bulldog2 4/10/10
Re: How Is Clomipramine Different From An SSRI? linkadge 4/10/10
Re: How Is Clomipramine Different From An SSRI? linkadge 4/10/10
Re: How Is Clomipramine Different From An SSRI? bulldog2 4/10/10
Re: How Is Clomipramine Different From An SSRI? viper1431 4/10/10
see you at the vetinary clinic manic666 4/11/10
Re: see you at the vetinary clinic ed_uk2010 4/11/10
Re: see you at the vetinary clinic hopefullynow 4/11/10
Re: see you at the vetinary clinic manic666 4/11/10
...
Re:clomipramine » bulldog2 conundrum 4/14/10

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