Posted by linkadge on November 11, 2009, at 15:30:47
In reply to Re: Litium is neuroprotective? You sure? Breggin?, posted by SLS on November 11, 2009, at 7:30:25
I'm not exactly sure of the association. If GSK-3b gets too high then (as SLS mentioned) there can be cell death. If GSK-3b gets too low there is also a reduction in some forms of placticity. GSK-3b is important for triggering axonal growth in the early stages of developement. GSK-3b inhibition is supposedly partially responsible for the tetarogenic effects of lithium and divalproex.
I also know that mild gsk-3b inhibition improves neurotransmission but if gsk-3b inhibition gets too low there are significant derangements in normal brain function (ie sensorimotory gating deficicts, latent inhibition issues). I think some studies have found that gsk-3b is dramatically reduced in schizophrenia.
Linkadge
poster:linkadge
thread:925110
URL: http://www.dr-bob.org/babble/20091107/msgs/925383.html