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Re: Fluoxetine = 5-HT2c Potent antagonist ? ..confused

Posted by JayBTV2 on August 7, 2008, at 11:41:14

In reply to Re: Fluoxetine = 5-HT2c Potent antagonist ? ..confused » JayBTV2, posted by Marty on August 6, 2008, at 11:30:19


> Hi, I respect your opinion, but I have to disagree with your rationale. Your logic is flawed because most AD with sexual side effects induce those because they STIMULATE 5-HT2c because of their reuptake inhibiion mecanism of action (more serotonin in the synaptic cleft "pushing buttons" more often.. 5-HT2c receptor being such button).... Agomelatine being a 5-HT2c ANTAGONIST, it REDUCE THE STIMULATION of the 5-HT2c receptor (the button is less frequently pushed).
>>

The title says " Fluoxetine = 5-HT2c Potent antagonist". That's why I assumed the two were similar. Are they both antagonists? Or was there a typo?

Either way I'm not too interested in the mechanics of why SSRIs cause sexual side-effects.

Like you I'm just waiting on Agomelatine and I'm glad that it works and doesn't cause these problems :)

Happy Thursday...

-Jay


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URL: http://www.dr-bob.org/babble/20080805/msgs/844780.html