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Fluoxetine = 5-HT2c Potent antagonist ? ..confused

Posted by Marty on August 5, 2008, at 19:39:36


5-HT2c is supposed to be the major culprit in the antidepressant sexual side effects. Fluoxetine is often reported has been one of the worst antidepressant when it comes to sexual side effects. Agreed ? .. now I stumble upon this:

"Have you ever given a dose of fluoxetine (Prozac) to a patient and had them have an activation? Fluoxetine is the only other drug that has powerful 5HT2C antagonist properties; in fact, fluoxetine has more powerful antagonist properties than reuptake blocking properties."

Source: " Schizophrenia: From Circuits to Symptoms
Stephen M. Stahl, MD, PhD. Improving Mood and Cognition: Serotonin 2C and 1A"

URL:
http://www.medscape.com/viewarticle/484929_5

If Prozac is one of the most potent 5-HT2C and end up being one of the worst at the sexual level then ... there's way more to the story than just 5-HT2C .. Any thoughts ?

/\/\arty

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poster:Marty thread:844424
URL: http://www.dr-bob.org/babble/20080805/msgs/844424.html