Posted by Amigan on April 12, 2008, at 19:15:06
In reply to Re: PEA or PLA with Selegiline??, posted by undopaminergic on April 12, 2008, at 17:53:56
> > > I may possibly have a pathologically low dopamine/noradrenaline ratio and ëxcessive dopamine beta-hydroxylase (DBH) activity, and others may be less sensitive to noradrenergic side-effects than I am. It may be interesting to test the effects of a alpha2-agonist like guanfacine, as it might improve the ratio in favour of dopamine, and seems to be the next best thing after DBH-inhibitors, which aren't clinically available.
> >
> > If only Carbidopa was able to cross the BBB..
>
> Excuse me? Carbidopa is primarily useful *because* it doesn't cross the BBB. As a peripheral inhibitor of aromatic amino acid decarboxylase (AADC) it helps greater amounts of L-dopa and 5-HTP (and other aromatic amino acids) cross the BBB before they are decarboxylated to dopamine and serotonin, which can't cross the BBB and hence have no CNS effect and furthermore cause unpleasant side effects like nausea, vomiting, diarrhoea, etc.I guess i wasn't thinking straight when i posted it. :-) My thought was that if it would be able to pass the BBB it would help the l-dopa which derives from the metabolism of PA/PEA to convert into dopamine inside the brain, more easily and hence improve your dopamine/NE ratio. Anyway, It doesn't make much sense now that i reconsider it...
> DBH converts dopamine to noradrenaline, and can be inhibited with research compounds like nepicastat and fusaric acid (while these may be worth trying, there are higher risks of unknown and potentially serious side effects).
>
> I actually tried L-dopa with a peripheral AADC inhibitor (benserazide), but it didn't seem to work, even with methylphenidate and selegiline, and with amisulpride there seemed to be increased side effects like muscle stiffness. I had expected that the stimulant effect of methylphenidate would be potentiated, but little or no such effects were noted.I have also tried l-dopa+Benseraside without any other meds, just coffee and i got only peripheral side effects: Nausea, vomiting and perhaps a small change in my muscle tone.
poster:Amigan
thread:822660
URL: http://www.dr-bob.org/babble/20080412/msgs/822945.html