Posted by FredPotter on March 4, 2007, at 19:10:57
In reply to Re: Atypical depression » bulldog2, posted by Ines on March 4, 2007, at 18:09:26
> > By the way rn320 suffered a bad hypertensive crisis on emsam 12 mg. So if your an emsam user and you're up to 12 mg be as careful as if you're on nardil or parnate.
> > Maybe the reason that maois are effective in atypical depression is they're the only ads that boost serotonin and dopamine which is the amine of pleasure. Maybe atypicals have some disruption of their dopamine pathways or levels. I've also read that ssris lower dopamine. No wonder many complain that they feel numb on ssris.
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> I believe wellbutrin is the only non MAOI AD that acts directly on dopamine? It acts on dopamine+noradrenaline/epinephrine. If it was the dopamine+ serotonin factor that made MAOIs effective then it could be that a combination of wellbutrin and an ssri would be effective as well. Any experiences? (I seem to remember reading that venlafaxine above a certain dose also acts on dopamine, but not sure about that)
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I've heard that too but the dose has to be high. Strangely I didn't find Wellbutrin effective. When I asked the pdoc if too much SSRI caused degradation of dopamine system he waved his hands about a lot, but as it was a hot day managed to keep the room really cool. But he did nothing about it.I want to try to persuade my GP to give me Nardil or buprenorphine. The alternative would be things that don't work, or ECT which they'd say I'm not bad enough for
Fred
poster:FredPotter
thread:737405
URL: http://www.dr-bob.org/babble/20070302/msgs/738348.html