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Drug holiday for tolerance/poop-out? » jlbl2l

Posted by Kon on May 9, 2004, at 15:14:13

In reply to neurontin poop out after awhile, fixable, chemist?, posted by jlbl2l on May 9, 2004, at 11:00:20

This wasn't adressed to me but I thought I'd post because I've very interested in this topic. I believe this is the norm with many drugs...taking a "drug holiday" often restores drug effect (ie. reverses tolerance or poop-out). Not sure if tolerance over the long-term develops faster with repeated cycling of drug. Based on my limited experience with tolerance to sedation side-effect of benzos, I think it may occur faster with repeated cycling of a drug.

I have read of recommendations for cycling neurontin and klonopin to prevent tolerance/poop-out. They recommend using klonopin until tolerance develops to it, then switch to a different class of drugs like neurontin and stay on it until tolerance/poop-out occurs then switch back to klonopin...keep repeating cycle. From what I've read... the longer the half life, the longer the drug will remain in the body and the longer the drug holiday should be to clear the drug out of one's body. Not sure how accurate this info is or how long cycles should be set based on half-lives???

Curious...what are some of these readily identifiable drug effect differences between neurontin and klonopin that you have?


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