Posted by chemist on April 10, 2004, at 21:27:22
In reply to Re: nortriptyline, citalopram toxicity » zeugma, posted by Vera on April 10, 2004, at 20:59:22
hi there, chemist again....i quote from forest pharmaceuticals white-paper: ``However, there are limited in vivo data suggesting a modest CYP2D6 inhibitory effect for escitalopram (lexapro), i.e., coadministration of (lexapro) (20 mg/day for 21 days) with the tricyclic antidepressant desipramine (single dose of 50 mg), a substrate for CYP2D6, resulted in a 40% increase in C_{max} and a 100% increase in AUC of desipramine...Nevertheless, caution is indicated in the coadministration of (lexapro) and drugs metabolized by CYP2D6.'' play it safe....best, chemist
> For Zeugma and Chemist -
>
> Hey, guys! Maybe a bit of English please!?? :-)
> I am now concerned about the combo of Pamelor and Lexapro??? Chem, are you saying, then, that I should stick with the Ativan 1mg, once daily, but increase the Lex10mg to twice a day?? Sorry to bother both of you again. I just want to feel normal - not comatose. :-) Thanks again.
poster:chemist
thread:328899
URL: http://www.dr-bob.org/babble/20040407/msgs/335047.html