Posted by Sad Panda on March 25, 2004, at 10:04:17
In reply to Re: Concurrent use of 2 Drugs Metabolized by 2d6 Enzym, posted by Ame Sans Vie on March 25, 2004, at 9:03:24
> Also, about inhibitors of 2D6 causing reduced efficacy of some drugs, this *does* happen in a few cases. Codeine, hydrocodone, oxycodone, and tramadol, for example, will not be (as) effective when administered with a 2D6-inhibitor. They all rely on this enzyme to convert to their prodrug forms -- morphine, hydromorphone, oxymorphone, and o-desmethyltramadol respectively.
>
>Wouldn't this just mean that the onset of effects is slower from these drugs?
Cheers,
Panda.
poster:Sad Panda
thread:327939
URL: http://www.dr-bob.org/babble/20040325/msgs/328174.html