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Re: Concurrent use of 2 Drugs Metabolized by 2d6 Enzym

Posted by Ame Sans Vie on March 25, 2004, at 9:03:24

In reply to Re: Concurrent use of 2 Drugs Metabolized by 2d6 Enzym » Lightshifter, posted by King Vultan on March 25, 2004, at 7:52:14

What King Vultan said is right on. I just also wanted to point out the fact that 2D6 is unique in that it is *uninducible*. No known drugs or foods speed up its processes -- certainly not the case for 1A2, 2C19, 3A4, and the rest.

Also, about inhibitors of 2D6 causing reduced efficacy of some drugs, this *does* happen in a few cases. Codeine, hydrocodone, oxycodone, and tramadol, for example, will not be (as) effective when administered with a 2D6-inhibitor. They all rely on this enzyme to convert to their prodrug forms -- morphine, hydromorphone, oxymorphone, and o-desmethyltramadol respectively.


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poster:Ame Sans Vie thread:327939
URL: http://www.dr-bob.org/babble/20040325/msgs/328156.html