Posted by cybercafe on July 13, 2002, at 0:20:54
In reply to More more more antidepressant theory, posted by Shawn. T. on July 12, 2002, at 21:59:24
> Awesome, thanks for your help. I haven't had time to do any reading on dopamine; what you told me is really fascinating. I can really put that information to good use! You really clued me in
maybe we are both being somewhat close-minded or tunnel-visioned... but personally i tend to judge serotonin neuroreceptors by their effects on dopamine release... since i know dopamine is responsible for cognitive functioning and the pleasure centers of the brain...
... i also find it interesting that dopamine increases arousal, libido, weight loss, decreases appetite, (eg wellbutrin) whereas 5HT2 blocks dopamine and causes sedation, decreased libido, weight gain, increased appetite etc ... (5HT2 may cause inhibition of orgasm by spinal motor neuron inhibition)... so i really wonder how many effects might be secondary rather than primary.....
>on 5-HT4 action as well. My interest in moving beyond 5-HT2 receptors (yes, that is my primary interest because of Remeron) has brought me away from serotonin and dopamine receptor research. I've been really into hormones recently if you haven't notice. There is definitely much more to
hmm.. is cortisol in the extracellular areas of the brain? .... and how does it cause depression? does it decrease cell firing in the pleasure centers of the brain?
>depression than serotonin, despite what SSRI producing companies would like you to believe. You should see how many IE windows I have open at once all the time (I try to keep it under 18).
... perhaps if you gave someone a drug that worked really well they wouldn't be able to stop themselves from taking more and more ?
> I am really blown away by evidence linking intelligence to depressive symptoms and lack of it to euphoria. I have an IQ of 135 or higher... where have you seen evidence to this effect? ...
>drugs by any means. You may be intrigued by the fact that Remeron+Wellbutrin has entirely curtailed my drug abuse.
... hows that?
> 5-HT5 receptors interact negatively with adenylyl cyclase. So their activation decreases adenylyl cyclase activity. That would seem to signal a decrease in cortisol. Another anti-depressant mechanism of serotonergic agents, perhaps? Also, a possible explanation of seasonal affective disorder?... i wonder if decreasing a secondary messenger might mean inhibiting the firing of a neuron which would be synonymous with depression... although some neurons will cause others to fire, some will inhibit the firing of other neurons so it's not that simple...
> Based on five minutes of reading, antagonists of 5-HT6 receptors appear to increase glutamate (excititory neurotransmitter) levels. That means cognitive enhancement without a doubt. I'll update you on more about this later.
... well it depends where... glutamate might excite a neuron that produces GABA and inhibits 1000 other neurons...
> You might be interested in my theory of SSRI related male sexual dysfunction. 5-HT1a activation in combination with 5-HT2a and 5-HT2c leads to increased prolactin excretion.i believe 5HT2A and 5HT2C decreases dopamine release, ... and D2 dopamine receptors in the pituitary release testosterone and increase libido
>makes your breasts larger. I can't wait for M,100,907 (the 5-HT2 selective antagonist) to be released.
what's wrong with ritanserin?> Also 5-HT1a agonists seem to cause up-regulation by the way. This makes me think that taking an SSRI after consuming MDMA really is a good idea.
up regulation means... compensating by increasing the number of neuroreceptors? ... but if you use an agonist.. and cause the neuron to fire more than usual.. wouldn't it adapt .. compensate.. by decreasing the number of neuroreceptors?> The increase in serotonin caused by an SSRI would prevent serotonin receptor up regulation in response to a massive serotonin decrease after taking MDMA.
... but then if you're wrong, you could die from serotonin syndrome or the opposite :)
> Something tells me this might spark your interest.
> http://www.tocris.com/cat/5ht567.htmlhmmm... was hoping for an explanation of what they actually do :)
poster:cybercafe
thread:111957
URL: http://www.dr-bob.org/babble/20020709/msgs/112183.html