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Natural selection, cortisol, and antidepressants

Posted by Shawn. T. on July 11, 2002, at 7:56:35

In reply to Some antidepressant theory, posted by Shawn. T. on July 10, 2002, at 17:16:30

http://www.biopsychiatry.com/depression/evolution.html
and
http://www.huxley.net/rankmood/index.html
and
http://www.huxley.net/rankmood/adapt.htm
and
http://www.biopsychiatry.com/depression/index.html
and
http://www-np.unimaas.nl/PsyPharm/postersBAP/posterwim.html
and
last but not least...
http://members.aol.com/jefferiesw/research/cortisone.html


I believe that these links help further my theory. I also believe that this shows a clear link between antidepressants that work on serotonin, cortisol, and natural selection. Might antidepressants improve fertility? Might they prevent miscarriage? This information also has powerful clues to possible causes of depression (heriditary, childhood abuse or neglect, starvation, high levels of stress, basically anything that causes increased levels of cortisol secretion). I believe this also furthers my claim that 5-HT2 antagonism is an important antidepressant mechanism and could possibly save lives.

"Meanwhile I also began to work in an infertility clinic associated with Western Reserve University and found that many of its women patients had evidence of mild disorders of adrenal function that improved when they were given small, subreplacement dosages of cortisone or cortisol (3). During the next twenty years over 200 babies were born to women with mild disorders of ovarian function who took safe, physiologic dosages of cortisone or cortisol not only in order to get pregnant but also throughout their pregnancies to protect against miscarriages, without any evidence or harm to either mothers or babies (4). These dosages therefore appeared to be restoring normal function rather than impairing it."


I believe that of all currently available antidepressants, Remeron is clearly the most effective because of its effects as an 5-HT2 antagonist. That doesn't mean it can't be improved upon, just that it's the best thing around right now.

See
http://www4.infotrieve.com/newmedline/detail.asp?NameID=10451911&loggedusing=M&Session=98474&SearchQuery=mirtazapine+AND++%28noradrenaline+OR+norepinephrine%29&count=56


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poster:Shawn. T. thread:111957
URL: http://www.dr-bob.org/babble/20020709/msgs/112025.html