Posted by Will_Hung on May 7, 2002, at 17:12:21
I'm currently taking 750mg/day in the form of 2x375mg divided dose with about 1.5 - 2 hours in between doses. Thing is, I want to get the maximum possible effect from this drug as I cant take the dose any higher and its served me quite well so far.
Anyway, I've read about something called the "first-pass effect" which apparently removes about 50% of a single dose of the drug from the body via the liver before it reaches the bloodstream. Multiple dosing means that about 85% of the the dose reaches the bloodstream. My question is this: if I am taking the drug divided over only a 2-hour period will my liver treat each days Moclobemide as a 'single dose' and remove 50% of it before it gets into my bloodstream? After all, the other 22-hours in between equals about 10 half-lives for moclobemide. In other words am I currently wasting half of my AD by not dividing the drug over a longer period of time (say 5-6 hours)?
Also, are side effects be affected by dividing the dose over a longer period of time?I hope that I have got my question(s) across well because as you can see its sort of complicated. I have looked for information on this on the internet but all I have found so far are university lecture notes on the liver!
Cheers
Will
poster:Will_Hung
thread:105468
URL: http://www.dr-bob.org/babble/20020503/msgs/105468.html