Posted by SLS on June 14, 2000, at 14:43:38
In reply to Scott and Karen: Sulpiride, ADHD, etc., posted by AndrewB on June 14, 2000, at 11:12:28
> Karen, I wanted to let you know about a paper on the net that talks about ADHD and drug treatment for it. It is very interesting. The author believes that ADHD is of dopaminergic origin as evidenced by his findings that selegiline and tyrosine, which both act solely on the dopamine system, were as effective as amphetamines on ADHD. This certainly would explain amineptine’s effectiveness for you. (BTW, I disagree with Scott that amineptine is a reuptake inhibtor of NE. It only is a reuptake inhibitor of dopamine. I think Peter J made it clear that there is an NE effect from amineptine but it is from some other mechanism than reuptake.......and how significant is it anyway?) You can find this paper at www.mhsource.com/pt/p960741.html
Thanks for the citations, Andrew. I smiled when I read the comments regarding glutamate and stress. That was one hell of a lucky guess. Perhaps I have something here. It will take me some time to review the whole article. I'm feeling like crap.It's ashame that amineptine had to go away. It may not have been the best antidepressant in the world, but it was a good tool. I hope it makes a reappearance. Ritalin is also a potent DA reuptake inhibitor. Have you ever tried combining it with amisulpride?
> Scott, I tried l-dopa with entacapone and selegiline. Seemed to give me a very good arousal, but it’s just one day and my first impressions are often way of base. Problem is that l-dopa does, as the amisulpride’s label instructions warned, contradict (or take away) the action of amisulpride and thus cause the return of depression and related symptoms.
I have a hard time imagining that l-dopa can displace amisulpride from PREsynaptic receptors, thereby reducing its antidepressant effects. Perhaps they were referring to amisulpride's antipsychotic effects. I would guess that this is the case.
I think amisulpride is sold under the trade name Deniban in Italy. I'm pretty sure its official indication is for depression, and it is sold in 50mg doses. Trivia.
> I don’t know what I’ll do next. Probably I’ll take the l-dopa combo again and see if the same thing happens. Considering Tasmar, the other, stronger COMT.
Is Tasmar due to be withdrawn from the US market? I know it has been withdrawn in several countries. How are you supposed to go about monitoring liver function?
- Scott
poster:SLS
thread:36813
URL: http://www.dr-bob.org/babble/20000610/msgs/37291.html