Posted by KarenB on June 13, 2000, at 11:54:05
In reply to Re: Incomplete recovery gaining attention, posted by SLS on June 10, 2000, at 9:39:52
> Perhaps low serotonin is never the cause.You may be right...
> Perhaps dopaminergic drugs make a good bandage to compensate for the underactivity of glutaminergic neurons afferent to the thalamus and hippocampus that have been downregulated due to their chronic overactivity in response to stress. This would allow for a perturbation of the balance between glutaminergic and GABAergic activity there in favor of efferent GABAergic neurons leading to the nucleus accumbens, whereby dopaminergic neurotransmission in this healthy structure is thus inhibited. What do you think?
I think I want a new brain.
By the way, you may remember that Amineptine combined with Sulpiride worked best for me. I'm trying to find alternatives here, stateside. Right now, it's Adderall and Buspar - OK but not totally there yet. I'm going to trial Modafinil starting next week - I have faxed info to doc (he knoweth not the med) and if he won't let me trial it, I go elsewhere. Adderall has me clenching my jaws by afternoon - but, at least I have energy. Like I said, OK but not great...
In your opinion, does the Amineptine/Sulpiride success indicate dopamine depletion? What up with the glutaminergic thing? Is it possible that GABA supplementation could help in a case like this or am I way off base?
Hope you are doing well.
karen
poster:KarenB
thread:36813
URL: http://www.dr-bob.org/babble/20000610/msgs/37161.html