Posted by Rick on June 10, 2000, at 16:42:37
In reply to More:Provigil poop out;klono counteracts provigil?, posted by Rick on June 10, 2000, at 16:32:05
(Let's continue, shall we?)
--To me, this is probably the best evidence of all that Provigil doesn't kill the effects of Klonopin: When I take my small afternoon dose of Klonopin (0.25mg), I can really FEEL it, even more so than before I started the Provigil. The two meds feel like they are *complementing* each other by treating different components of my Social Phobia.
Anyways, those are just a few of my thoughts regarding the possibility of Klonopin and Proigil working at cross-purposes. Theory and narrowly-focused, vaguely-suggestive rat-brain studies aside, for me the bottom line is that everything other treatment I've tried has paled beside this combo. (Although I should reiterate that 1.5-2.0 mg Klonopin alone helped me an awful lot. What I'm doing now is "going for the gold".)
I'm thrilled with my Social Phobia cocktail of Serzone, Klonopin, and Provigil.Rick
-----> >I just hope what some have said about a tendency
> >for Provigil to poop out doesn't surface for me.
> >
> Maybe some of our resident pharmacology/neurochemistry experts can help out, but aren't Klonopin and Provigil kind of opposite? (Klonopin increasing GABA(†) and Provigil (modafinil) decreasing it(‡) ). Does this suggest any danger besides the two possibly counteracting each other's effect to some extent?
>
> † sorry, no ref. for this but I believe it's right
>
> ‡ "The effects of modafinil on glutamatergic and GABAergic transmission in the rat medial preoptic area (MPA) and posterior hypothalamus (PH), are analysed. Modafinil (30-300 mg/kg) increased glutamate and decreased GABA levels in the MPA and PH."
> - from (according to http://www.modafinil.com/glutam.html):
> "The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade"
> by
> Ferraro L, Antonelli T, Tanganelli S, O'Connor WT,
> Perez de la Mora M, Mendez-Franc
poster:Rick
thread:36517
URL: http://www.dr-bob.org/babble/20000610/msgs/36863.html