Posted by SLS on June 3, 2000, at 9:26:37
In reply to history - Jennifer, posted by Elizabeth on June 3, 2000, at 7:50:15
> > Mirapex does lower your blood pressure though, and since Nardil was originally for lowering blood pressure (and then when everyone was in a good mood, they found a new use for it!) you may get a double whammy of low b/p.
> There was an MAOI - Eutonyl (pargyline) - that popped up at some point and was used as an antihypertensive, but it's no longer available AFAIK.
I don't think pargyline is terribly effective as an antidepressant. One reason may be that it is fairly selective for MAO-B. An interesting lessen in trying to infer drug activities based upon molecular heritage (not that you need one) is that a propargyl cousin of pargyline, deprenyl is also selective for MAO-B, while another cousin, clorgyline, is specific for MAO-A.
> BTW, I wouldn't necessarily trust anything a pharmacist said about MAOIs. IME, they tend to get a lot of things wrong, especially in regard to interactions; I pretty much feel I can count on them to parrot the PDR (though there are exceptions). I attribute this to a lack of real clinical experience.
Except for Cam W. :-)
Dear Elizabeth,Does Mirapex, or any of the other DA agonists, potentiate the hypotensive effect of Nardil or any of the other MAOIs? I didn't experience this when I added Parlodel to Parnate + desipramine.
Oh, and while I've got you here, I'm having trouble deciding whether to use Nardil or Parnate for treating my bipolar depression. I am aware of the traditional choice of Parnate in this situation. However, having experienced a partial response to both, I like the way I feel on Nardil better. It is becoming increasingly apparent that anhedonia can persist in many people who otherwise respond robustly to Parnate. A confounding factor is that I will be using a tricyclic along with either MAOI. I experience one hell of a synergism between Nardil and a tricyclic with regard to hypotension and the ability to initiate urination. Imipramine is out, although it is probably more effective. I will be using desipramine, and will be throwing in as much other crap as I can find.
Any suggestions?
Any opinions on Gabitril?
What is your gut-reaction to Tegretol?
I will be eternally grateful if you would be kind enough to cure me.
Sincerely,
Scott
poster:SLS
thread:34894
URL: http://www.dr-bob.org/babble/20000603/msgs/35830.html