Posted by Elizabeth on June 3, 2000, at 7:40:41
In reply to Re: Vitamin B-6 and MAOIs, posted by kate99999 on May 31, 2000, at 15:24:36
> > Was the research specific to Nardil, or do other MAOIs also cause B6 depletion?
>
> Well, this originally came from Elizabeth on alt.support.depression.medications mentioning hydrazine-based compounds (of which Nardil is one) can deplete B6. It's under the thread "Nardil side effects..." So she'd be the one to ask which MAOIs are and aren't hydrazine-based.Nardil and Marplan are hydrazine derivatives (so is Marsilid, which is no longer used AFAIK). Parnate is not. Selegiline is not.
The research was specific to Nardil (I don't believe Marplan has been looked at specifically), but it is also true (as I mentioned on ASDM) that other hydrazine-like drugs (such as isoniazid) have this potential side effect. At the same time, Nardil and Marplan aren't chemically identical, and it's possible that some of the small differences could be relevant.
> The research I saw was just about Nardil (phenelzine). But then I'd only looked up phenelzine and pyroxidine, not parnate and pyroxidine.
(You might try pyridoxal phosphate - the form of B6 that's active in your body - too.)
poster:Elizabeth
thread:34894
URL: http://www.dr-bob.org/babble/20000603/msgs/35818.html