A full agonist would be something that has the maximal effect at the receptor..." /> A full agonist would be something that has the maximal effect at the receptor..." />
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Re: Buspar - "partial" agonist?

Posted by Scott L. Schofield on November 19, 1999, at 9:23:59

In reply to Re: Buspar - "partial" agonist?, posted by Elizabeth on November 18, 1999, at 1:31:31

> > I often see buspirone (Buspar) described as being a "partial" agonist at 5-HT1a receptor sites.

> > 1. What does "partial" mean?

> A full agonist would be something that has the maximal effect at the receptor. (Serotonin, for example, is a full agonist at the 5-HT1a receptor.) A partial agonist has less than the full effect.

Next question.

Is this less-than-full effect the result of a weaker binding affinity or due to a lack of stimulation of the receptor, even though it may be tightly bound?

Thanks again.

Oh yeah... Next question

I was under the impression that there is a high density of axono-dendridic 5-HT1a autoreceptors. Are these inhibitory or excitatory?

Thanks again.

Oh yeah... Oh forget it.


- Scott

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poster:Scott L. Schofield thread:15384
URL: http://www.dr-bob.org/babble/19991108/msgs/15527.html