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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by PeterMartin on February 1, 2019, at 1:23:15
At least I think that's what this new study is saying. Hope this doesn't mean the price is going to skyrocket :/
https://www.ncbi.nlm.nih.gov/pubmed/306935392019 Jan 28.
Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells.
Gaur S1, Gross ME2, Liao CP2, Qian B1, Shih JC1,3,4.Abstract
Monoamine oxidase A (MAOA) is best known for its role in neuro-transmitter regulation. Monoamine oxidase inhibitors are used to treat atypical depression. MAOA is highly expressed in high grade prostate cancer and modulates tumorigenesis and progression in prostate cancer. Here, we investigated the potential role of MAOA inhibitors (MAOAIs) in relation to the androgen receptor (AR) pathway and resistance to antiandrogen treatment in prostate cancer.METHODS:
We examined MAOA expression and the effect of MAOI treatment in relation to AR-targeted treatments using the LNCaP, C4-2B, and 22Rv1 human prostate cancer cell lines. MAOA, AR-full length (AR-FL), AR splice variant 7 (AR-V7), and PSA expression was evaluated in the presence of MAOAIs (clorgyline, phenelzine), androgenic ligand (R1881), and antiandrogen (enzalutamide) treatments. An enzalutamide resistance cell line was generated to test the effect of MAOAI treatment in this model.RESULTS:
We observed that MAOAIs, particularly clorgyline and phenelzine, were effective at decreasing MAOA activity in human prostate cancer cells. MAOAIs significantly decreased growth of LNCaP, C4-2B, and 22Rv1 cells and produced additive growth inhibitory effects when combined with enzalutamide. Clorgyline decreased expression of AR-FL and AR-V7 in 22Rv1 cells and was effective at decreasing growth of an enzalutamide-resistant C4-2B cell line with increased AR-V7 expression.CONCLUSIONS:
MAOAIs decrease growth and proliferation of androgen-sensitive and castration-resistant prostate cancer cells. Clorgyline, in particular, decreases expression of AR-FL and AR-V7 expression and decreases growth of an enzalutamide-resistant cell line. These findings provide preclinical validation of MAOA inhibitors either alone or in combination with antiandrogens for therapeutic intent in patients with advanced forms of prostate cancer.
Posted by alexandra_k on February 1, 2019, at 21:08:44
In reply to Nardil may help prevent Prostate Cancer, posted by PeterMartin on February 1, 2019, at 1:23:15
> At least I think that's what this new study is saying. Hope this doesn't mean the price is going to skyrocket :/
I don't think the price of medications tends to increase over time, more likely decrease.
It looks like they are trying to increase profits by broadening the patient base.
A relatively easy way to do that is by looking at side-effects and seeing if side-effects could potentially help some people.
E.g., if a medication lowers androgen levels or decreases androgen receptors or something like that then may be it can help with disorders which involve over-activity of androgen receptors or androgen levels or something like that.
I don't know much about prostate cancer. I heard in these parts that something like... It might have been 1/3 or it might have been as high as 2/3 of men have enlarged prostate when they die. Enlarged prostate will progress to cancer if it enlarges for long enough. But the treatments for enlarged prostate involve supressing / descreasing levels of androgens and guys tend not to like the way it makes them feel. so guys tend not to want to take the medication. And surgical removal gone wrong would be unacceptable to many, too...
I guess Nardil might be a gentler way.
I don't know.
Posted by linkadge on February 2, 2019, at 7:49:57
In reply to Re: Nardil may help prevent Prostate Cancer, posted by alexandra_k on February 1, 2019, at 21:08:44
If the demand increased for the med, this might help ensure the drug stays in production at a decent cost (i.e. increased supply).
That being said, I don't think it will be used in clinical practice for prostate cancer (mainly because of side effects / dietary restrictions).
Turmeric (a MAOI) with anti-cancer effects independent of its MAO action, might be worth testing in this regard.
Linkadge
Posted by PeterMartin on February 2, 2019, at 10:15:08
In reply to Re: Nardil may help prevent Prostate Cancer, posted by linkadge on February 2, 2019, at 7:49:57
> If the demand increased for the med, this might help ensure the drug stays in production at a decent cost (i.e. increased supply).
>
> That being said, I don't think it will be used in clinical practice for prostate cancer (mainly because of side effects / dietary restrictions).
>
> Turmeric (a MAOI) with anti-cancer effects independent of its MAO action, might be worth testing in this regard.
>
> LinkadgeOr maybe they'll market a new irreversible MAOI in Clorgyline! :)
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