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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by rjlockhart37 on July 28, 2016, at 20:03:14
there's no changes going on with now, but i did ask my doctor about Marplan, she said it is a effecctive antidepressant .... im on the max prozac with some benefits, but i've kept marplan in mind for a while
the only thing is it says you cannot take dextroamphetamine, and various other things with it.....i didnt know you can't take psychostimulants with MAOI's.....you can take Parnate with dextroamphetamine but you cannot with marplan from what i read on google
does anyone have any suggestive experiences with Marplan? prozac keeps me out of depressive states, but if marplan is stronger maybe it would be an option
?
Posted by Horse on July 29, 2016, at 3:02:05
In reply to Marplan - keeping it in mind, posted by rjlockhart37 on July 28, 2016, at 20:03:14
I didn't know Marplan was available in the US if I'm thinking of the right name.
> there's no changes going on with now, but i did ask my doctor about Marplan, she said it is a effecctive antidepressant .... im on the max prozac with some benefits, but i've kept marplan in mind for a while
>
> the only thing is it says you cannot take dextroamphetamine, and various other things with it.....i didnt know you can't take psychostimulants with MAOI's.....you can take Parnate with dextroamphetamine but you cannot with marplan from what i read on google
>
> does anyone have any suggestive experiences with Marplan? prozac keeps me out of depressive states, but if marplan is stronger maybe it would be an option
>
> ?
Posted by PeterMartin on July 29, 2016, at 16:45:18
In reply to Re: Marplan - keeping it in mind » rjlockhart37, posted by Horse on July 29, 2016, at 3:02:05
I take Marplan and it works for me. I've been on it for so long thought that its difficult to say how much it helps since I also take lamictal and a little seroquel. It's milder than Nardil or Parnate but I haven't had weight gain issues like many do w nardil.
Also you should take dextomethophan with ANY maois. Not sure where you saw you can take it with Parnate but that's almost certainly not correct.
Prozac has a long half life I think so it may take a while to make the switch if you have a conservative doctor.....
Posted by PeterMartin on July 29, 2016, at 16:47:40
In reply to Re: Marplan - keeping it in mind, posted by PeterMartin on July 29, 2016, at 16:45:18
>
> Also you **shouldn't** take dextomethophan with ANY >maois. Not sure where you saw you can take it with >Parnate but that's almost certainly not correct.
>Sorry typo in last post. You should not combine dextromethorphan with an maoi.
Posted by rjlockhart37 on July 29, 2016, at 22:50:32
In reply to Re: Marplan - keeping it in mind, posted by PeterMartin on July 29, 2016, at 16:47:40
thanks.....i'm on 80mg of prozac and i do notice if i don't take it i do get into depressive states, but i've been on it so long my body adapted to it and it's hard to notice major antidepressant effects. Marplan i've read about, it's a good effective antidepressant, i would love to try it not for just trying it, but it's strong antidepressant effect to keep me from gloom and dark mood states
do you just feel better and back to normal? relieving from depression with marplan?
Posted by Horse on July 30, 2016, at 12:31:21
In reply to Re: Marplan - keeping it in mind, posted by rjlockhart37 on July 29, 2016, at 22:50:32
Hi rj, I'm sorry to hear you're experiencing depressive states. I don't think Marplan is available in the US, so I don't know why you're interested.
Would looking into another antidressant be better? It has the same risk as other MAOI's.
Posted by PeterMartin on July 30, 2016, at 15:25:29
In reply to Re: Marplan - keeping it in mind » rjlockhart37, posted by Horse on July 30, 2016, at 12:31:21
> Hi rj, I'm sorry to hear you're experiencing depressive states. I don't think Marplan is available in the US, so I don't know why you're interested.
>I'm in the US and yes it's available. It's expensive (sometimes even w/ insurance) but I've been on it since 2010. A small Pharmaceutical company called Validus makes it now: http://marplan.com/
RJ>
It definitely got me out of a depression to the point where I felt normal. I remember when I started it I got to a low dose of 20mg and was satisfied enough to not go higher which was unusual for me. I stopped taking it for a few months early in 2015 when I though my insurance was going to stop covering it (per a letter). I eventually went back on it due to depression returning and getting it approved and now I'm using 50mg (60mg is max). It definitely helps.
Prozac was one of the other meds I did have success w/ in the past btw. Since Prozac has a very long half life (I think it's like a week?). You may be better off trying something else w/ a shorter half life first. You're supposed to do a washout when switching from SSRI to MAOI of 14days but that might be longer w/ a med like Prozac that stays around for so long.
Good luck if you give it a try.
Posted by Horse on July 31, 2016, at 2:02:39
In reply to Re: Marplan - keeping it in mind, posted by PeterMartin on July 30, 2016, at 15:25:29
Peter, could you talk about why you chose Marplan out of the other MAOI's? Most folks take Nardil or Parnate.
rj, I'm hoping you find a med that consistently holds you afloat.
Posted by SLS on July 31, 2016, at 8:06:37
In reply to Re: Marplan - keeping it in mind, posted by PeterMartin on July 30, 2016, at 15:25:29
Hi.
> It definitely got me out of a depression to the point where I felt normal. I remember when I started it I got to a low dose of 20mg and was satisfied enough to not go higher which was unusual for me. I stopped taking it for a few months early in 2015 when I though my insurance was going to stop covering it (per a letter). I eventually went back on it due to depression returning and getting it approved and now I'm using 50mg (60mg is max). It definitely helps.
>
> Prozac was one of the other meds I did have success w/ in the past btw. Since Prozac has a very long half life (I think it's like a week?). You may be better off trying something else w/ a shorter half life first. You're supposed to do a washout when switching from SSRI to MAOI of 14days but that might be longer w/ a med like Prozac that stays around for so long.Prozac -> MAOI = 5 weeks.
Your idea is extremely logical. I would not have thought of it.
Have you lost any efficacy with your return to Marplan?
At what point did you lose your response to Prozac?
I had a partial response to Effexor 300 mg/day that was enhanced by the addition of nortriptyline 75 mg/day (which was later found to be too low a dosage for me). For me, I would consider going back to Effexor 375 mg/day + nortriptyline 100 mg/day if my current regime built around Parnate should not bring me to at least 75% remission.
I tried Marplan for only 2 weeks for lack of patience. I don't think it made me feel any worse. It was much more tolerable than Nardil.
- Scott
Posted by Escapee on August 5, 2016, at 7:41:40
In reply to Marplan - keeping it in mind, posted by rjlockhart37 on July 28, 2016, at 20:03:14
> there's no changes going on with now, but i did ask my doctor about Marplan, she said it is a effecctive antidepressant .... im on the max prozac with some benefits, but i've kept marplan in mind for a while
>
> the only thing is it says you cannot take dextroamphetamine, and various other things with it.....i didnt know you can't take psychostimulants with MAOI's.....you can take Parnate with dextroamphetamine but you cannot with marplan from what i read on google
>
> does anyone have any suggestive experiences with Marplan? prozac keeps me out of depressive states, but if marplan is stronger maybe it would be an option
>
> ?Hey. I'm just coming off Marplan and switching back to Nardil after 10yrs. Differences? I would say Marplan is the stronger antidepressant and you can really bully it too, with dosage and a good few ad-dons. Anxiety? You will probably find u need a benzo or some other anxiolitic. Nardil of course already decreases ones anxiety by itself. Side effects are the same. Urine retention (keep an eye on those kidneys;). Constipation, ILL SEXUAL HEALTH! Viagra don't do diddly. And low postural hypo-tension.
Yea, Parnate doesn't seem to interact with NRI's (inc amphetamine). In fact it helps protect against hypertensive crises. A study done using Parnate and Edronax (reboxetine). Not sure about Dexedrine's DRI effects on Marplan or Nardil. Posibly too much.
As with Nardil, Marplans side effects WILL GO, slooowly. Just need to be darn patient!Good luck!
Escapee
This is the end of the thread.
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