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Dr. Bob is Robert Hsiung, MD,
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Posted by Horse on September 18, 2015, at 8:03:14
Anyone know why an AD might cause nausea?
I'm just curious if there is some theory....
Posted by SLS on September 18, 2015, at 9:18:10
In reply to AD related nausea, posted by Horse on September 18, 2015, at 8:03:14
> Anyone know why an AD might cause nausea?
>
> I'm just curious if there is some theory....One explanation is that the nausea produced by SRIs is due to the increase in the stimulation of 5-HT3 receptors resulting from serotonin reuptake inhibition. Over time, this nausea may dissipate on its own as 5-HT3 receptors downregulate. This would take a few weeks.
Ondansetron (Zofran) is a 5-HT3 receptor antagonist often used to treat nausea. It would probably reduce SRI-induced nausea acutely if necessary. So far, I cannot find any reports of rebound nausea occurring once the drug is discontinued.
- Scott
Posted by Horse on September 18, 2015, at 14:22:53
In reply to Re: AD related nausea » Horse, posted by SLS on September 18, 2015, at 9:18:10
I might ask my doctor about zofran next week. I imagine a 5-ht3 antagonist will not affect my ad response.... I find it curious that the two most effective AD's to date, Cymbalta and now Brintellix, triggered persistent nausea.
Thanks Scott...hope you're well enough today x
This is the end of the thread.
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