Re: AD related nausea » Horse

Posted by SLS on September 18, 2015, at 9:18:10

In reply to AD related nausea, posted by Horse on September 18, 2015, at 8:03:14

> Anyone know why an AD might cause nausea?
>
> I'm just curious if there is some theory....
One explanation is that the nausea produced by SRIs is due to the increase in the stimulation of 5-HT3 receptors resulting from serotonin reuptake inhibition. Over time, this nausea may dissipate on its own as 5-HT3 receptors downregulate. This would take a few weeks.
Ondansetron (Zofran) is a 5-HT3 receptor antagonist often used to treat nausea. It would probably reduce SRI-induced nausea acutely if necessary. So far, I cannot find any reports of rebound nausea occurring once the drug is discontinued.

- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
- George Bernard Shaw

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AD related nausea Horse 9/18/15
Re: AD related nausea » Horse SLS 9/18/15
Re: AD related nausea » SLS Horse 9/18/15

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