Psycho-Babble Medication Thread 1074164

Shown: posts 1 to 17 of 17. This is the beginning of the thread.

 

Trying low-dose naltrexone (LDN).

Posted by SLS on December 12, 2014, at 7:53:16

I'm working with a new doctor who would like me to try LDN. I will be taking 4.5 mg at night. I took my first dose last night. So far, I don't feel any different and have no side effects.

I really don't know what to expect. I'll try not to think about it too much.


- Scott

 

Re: Trying low-dose naltrexone (LDN). » SLS

Posted by Phillipa on December 12, 2014, at 9:02:28

In reply to Trying low-dose naltrexone (LDN)., posted by SLS on December 12, 2014, at 7:53:16

I googled it. If used for alcoholism why for depression? Blocks the feel good opiod feelings. Did say most feel nothing. Did you go off the parnate to take this med? I wish you the best of luck. Phillipa

 

Lou's request-cnvrt » SLS

Posted by Lou Pilder on December 12, 2014, at 10:20:02

In reply to Trying low-dose naltrexone (LDN)., posted by SLS on December 12, 2014, at 7:53:16

> I'm working with a new doctor who would like me to try LDN. I will be taking 4.5 mg at night. I took my first dose last night. So far, I don't feel any different and have no side effects.
>
> I really don't know what to expect. I'll try not to think about it too much.
>
>
> - Scott
Scott,
You wrote that you are now attempting to use an unproven scientific method prescribed by a doctor as low dose naltrexone. I assume that you are attempting to somehow change the condition that you are in now by doing so.
But it is much more than that, for I think that if you convert from that type of thinking to the type of thinking that I could show you to convert to, that you could end your quest to find a drug that could alleviate the issues that you have that you are seeking drugs from a doctor/psychiatrist to somehow alleviate before the drugs kill you or induce a life-ruining condition and/or addiction.
This conversion could IMHO lead you into a new life free from drugs and addiction and depression. If you are interested in this conversion, take this opportunity to have dialog with me here by posting that you would like to convert.
Lou

 

Re: Trying low-dose naltrexone (LDN). » Phillipa

Posted by SLS on December 12, 2014, at 11:05:18

In reply to Re: Trying low-dose naltrexone (LDN). » SLS, posted by Phillipa on December 12, 2014, at 9:02:28

> I googled it. If used for alcoholism why for depression? Blocks the feel good opiod feelings. Did say most feel nothing. Did you go off the parnate to take this med? I wish you the best of luck. Phillipa

What were the dosages used for alcoholism?

Thanks for investigating.


- Scott

 

Re: Lou's request-cnvrt » Lou Pilder

Posted by SLS on December 12, 2014, at 11:11:13

In reply to Lou's request-cnvrt » SLS, posted by Lou Pilder on December 12, 2014, at 10:20:02

Hi Lou.

I am greatly appreciative of your concern for my health and general welfare. Let me think about your offer. I am hesitant to discuss this on the Mediation board, though.

Thanks, Lou.


- Scott

----------------------------------------------

> > I'm working with a new doctor who would like me to try LDN. I will be taking 4.5 mg at night. I took my first dose last night. So far, I don't feel any different and have no side effects.
> >
> > I really don't know what to expect. I'll try not to think about it too much.
> >
> >
> > - Scott


> Scott,
> You wrote that you are now attempting to use an unproven scientific method prescribed by a doctor as low dose naltrexone. I assume that you are attempting to somehow change the condition that you are in now by doing so.
> But it is much more than that, for I think that if you convert from that type of thinking to the type of thinking that I could show you to convert to, that you could end your quest to find a drug that could alleviate the issues that you have that you are seeking drugs from a doctor/psychiatrist to somehow alleviate before the drugs kill you or induce a life-ruining condition and/or addiction.
> This conversion could IMHO lead you into a new life free from drugs and addiction and depression. If you are interested in this conversion, take this opportunity to have dialog with me here by posting that you would like to convert.
> Lou

 

Re: Trying low-dose naltrexone (LDN).

Posted by ed_uk2010 on December 12, 2014, at 11:13:46

In reply to Trying low-dose naltrexone (LDN)., posted by SLS on December 12, 2014, at 7:53:16

I'm not sure I can claim to offer as much as Lou, but I'll still contribute to your thread.

>I'm working with a new doctor who would like me to try LDN. I will be taking 4.5 mg at night. I took my first dose last night. So far, I don't feel any different and have no side effects.

I assume the idea is to up-regulate the opioidergic system, perhaps by increasing receptor sensitivity. The night time dosing and moderate half-life of naltrexone might allow you to feel some positive effects during the day.

>I really don't know what to expect.

Diffucult to predict but I think it will take several days and maybe a couple of weeks to feel anything. I wouldn't expect anything yet.


 

Re: Trying low-dose naltrexone (LDN).

Posted by ed_uk2010 on December 12, 2014, at 11:37:25

In reply to Re: Trying low-dose naltrexone (LDN). » Phillipa, posted by SLS on December 12, 2014, at 11:05:18

>What were the dosages used for alcoholism?

Naltrexone (full dose) seems to decrease the pleasure response to alcohol. The effect is variable but in some cases it can actually make alcohol aversive. Another antagonist, nalfemene (Selincro) is approved for the reduction of drinking in Europe.

 

Re: Trying low-dose naltrexone (LDN).

Posted by Phillipa on December 12, 2014, at 17:32:16

In reply to Re: Trying low-dose naltrexone (LDN)., posted by ed_uk2010 on December 12, 2014, at 11:37:25

Scott here is one that discusses dosing. I know that you will be able to figure out how compares to what you are taking dose wise. Phillipa

http://www.drugs.com/vivitrol.html

 

Re: Trying low-dose naltrexone (LDN).

Posted by baseball55 on December 12, 2014, at 19:51:09

In reply to Re: Trying low-dose naltrexone (LDN)., posted by Phillipa on December 12, 2014, at 17:32:16

I don't really understand LDN. Naltrexone blocks opiate receptors so that opiates have no psychological affects. I took 50mg for a year after I withdrew from opiate addiction. My husband gave it to me every night.

I drank while taking it. It did not in any way change my response to alcohol. Why would it? Alcohol doesn't bind with opiate receptors. I know a lot of alcoholics and none of them had a response to naltrexone.

So, 1/10 the dose for depression. What's the theory here?

 

Re: Trying low-dose naltrexone (LDN). » baseball55

Posted by SLS on December 12, 2014, at 20:13:12

In reply to Re: Trying low-dose naltrexone (LDN)., posted by baseball55 on December 12, 2014, at 19:51:09

> I don't really understand LDN. Naltrexone blocks opiate receptors so that opiates have no psychological affects. I took 50mg for a year after I withdrew from opiate addiction. My husband gave it to me every night.
>
> I drank while taking it. It did not in any way change my response to alcohol. Why would it? Alcohol doesn't bind with opiate receptors. I know a lot of alcoholics and none of them had a response to naltrexone.
>
> So, 1/10 the dose for depression. What's the theory here?

That's a good question.

I'm not totally sure. If it works anything like certain antipsychotics (sulpiride; amisulpride) do on dopamine, it has opposite effects at low dosages due to the suppression of the negative feedback loop that would otherwise suppress neurotransmitter manufacture and release. I really should look into it. Thanks for motivating me.

:-)


- Scott

 

Re: Trying low-dose naltrexone (LDN). » baseball55

Posted by SLS on December 12, 2014, at 20:15:47

In reply to Re: Trying low-dose naltrexone (LDN)., posted by baseball55 on December 12, 2014, at 19:51:09

Hi.

"In different areas of the human body, and especially the brain, opioid receptors can do more than relieve pain. Primarily, these receptors bind endogenous (originating within the human body) pain-relieving compounds, such as endorphins. Semi-synthetic compounds, like heroin, also stimulate these receptors. There appears to be a feedback loop, where blocking these receptors a little may cause an increase in endorphin production."

http://www.msfocus.org/article-details.aspx?articleID=810


- Scott

 

Re: Trying low-dose naltrexone (LDN). » SLS

Posted by Phillipa on December 12, 2014, at 21:36:11

In reply to Re: Trying low-dose naltrexone (LDN). » baseball55, posted by SLS on December 12, 2014, at 20:15:47

The study is based on MS and autoimmune diseases. So you thinking that depression could end up an autoimmune disease. Have you had your ANA checked seriously. As that is an indicator of autoimmune illnesses. Mine was sky high when active Lymes Disease So maybe there is some autoimmune factor there. Interestingly at the time in the hospital I had both an infection control specialist, and a rheumatologist who thought I had what he referred to as a miss mash of autoimmune illnesses. But I was diagnosed negative for MS? Phillipa

 

Re: Trying low-dose naltrexone (LDN).

Posted by PeterMartin on December 13, 2014, at 2:15:19

In reply to Re: Trying low-dose naltrexone (LDN). » baseball55, posted by SLS on December 12, 2014, at 20:13:12

Good luck! If you happen to notice any weight change please do mention that...

A combo of LDN and Bupropion was recently approved as a weight loss med called Contrave:: http://en.wikipedia.org/wiki/Bupropion/naltrexone

I'm still on a MAOI so might not be able to make it at this point but definetly going to talk to my pdoc in Jan.

 

Re: Trying low-dose naltrexone (LDN). » PeterMartin

Posted by ed_uk2010 on December 13, 2014, at 6:23:00

In reply to Re: Trying low-dose naltrexone (LDN)., posted by PeterMartin on December 13, 2014, at 2:15:19

> Good luck! If you happen to notice any weight change please do mention that...
>
> A combo of LDN and Bupropion was recently approved as a weight loss med called Contrave: http://en.wikipedia.org/wiki/Bupropion/naltrexone

Everything in weight loss seems to be a combination lately :) First phentermine/topiramate and now this one. I suspect you'd need more than 4.5mg naltrexone to produce any significant weight loss, but higher doses can produce some effect alone - which is then enhanced by bupropion in the combo med.

 

Re: Trying low-dose naltrexone (LDN). » baseball55

Posted by ed_uk2010 on December 13, 2014, at 6:28:28

In reply to Re: Trying low-dose naltrexone (LDN)., posted by baseball55 on December 12, 2014, at 19:51:09

>I drank while taking it. It did not in any way change my response to alcohol.

.......Why would it? Alcohol doesn't bind with opiate receptors.

Not directly not, but it interacts with the function of the opioidergic system.

>I know a lot of alcoholics and none of them had a response to naltrexone.

A lot don't. The genetics of this are at least partially understood (surprisingly). Response to naltrexone in alcoholism is associated with the presence of certain genes. This is thought to be reason people of African origin very rarely respond to naltrexone for alcoholism - the gene is almost never present in this group. It is, however, very common in certain Asian groups, and a moderate proportion of white Europeans.

 

Re: Trying low-dose naltrexone (LDN).

Posted by SLS on December 17, 2014, at 4:29:00

In reply to Trying low-dose naltrexone (LDN)., posted by SLS on December 12, 2014, at 7:53:16

> I'm working with a new doctor who would like me to try LDN. I will be taking 4.5 mg at night. I took my first dose last night. So far, I don't feel any different and have no side effects.
>
> I really don't know what to expect. I'll try not to think about it too much.

I have been deteriorating. Yesterday was especially bad:

1. Flat affect
2. Anergia
3. Anhedonia
4. Loss of interest and motivation
5. Psychic or mental pain (psychalgia)

I skipped last night's dose of LDN. This morning, I feel pretty good. I don't wish to perform a rechallenge in order to be sure that it was the naltrexone that was responsible for my feeling worse. Time to place a check mark next to LDN.

I don't know. Maybe the dosage of 4.5 mg was too high.


- Scott

 

Re: Trying low-dose naltrexone (LDN). » SLS

Posted by Phillipa on December 17, 2014, at 8:59:53

In reply to Re: Trying low-dose naltrexone (LDN)., posted by SLS on December 17, 2014, at 4:29:00

I know the feeling only mine is different but I'm sorry. If only we all could just get better like getting over strep throat. Phillipa


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