Posted by ed_uk2010 on December 13, 2014, at 6:28:28
In reply to Re: Trying low-dose naltrexone (LDN)., posted by baseball55 on December 12, 2014, at 19:51:09
>I drank while taking it. It did not in any way change my response to alcohol.
.......Why would it? Alcohol doesn't bind with opiate receptors.
Not directly not, but it interacts with the function of the opioidergic system.
>I know a lot of alcoholics and none of them had a response to naltrexone.
A lot don't. The genetics of this are at least partially understood (surprisingly). Response to naltrexone in alcoholism is associated with the presence of certain genes. This is thought to be reason people of African origin very rarely respond to naltrexone for alcoholism - the gene is almost never present in this group. It is, however, very common in certain Asian groups, and a moderate proportion of white Europeans.
poster:ed_uk2010
thread:1074164
URL: http://www.dr-bob.org/babble/20141120/msgs/1074195.html