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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Scout2020 on December 8, 2014, at 19:52:56
Nuedexta is prescribed off-label for TRD.It purportedly works on the same areas of the brain as Ketamin, without the same side-effects. Has anyone had experience with Nuedexta for depression?
Thanks
Posted by PeterMartin on December 9, 2014, at 2:23:11
In reply to Nuedexta, posted by Scout2020 on December 8, 2014, at 19:52:56
I used to use DXM (dextromethorohan) which is probably the past of that w the A/D effect. Definitely helpful but with significant dosages you trip. It was a bad time in my life with drugs but I used to down bottles of robitussin (only the pure dextromethorphan kind: long acting cough). One bottle would really help get to get me to a nice sense of clarity - remove any social anxiety. I found Lamictal really blunted the effects (ie I wouldn't tech the point of tripping) but I'd still get relief from the depression/anxiety......
I'm definitely a believer in drugs that work with NMDA receptors. I don't think DXM is the answer though. You could just try small doses of OTC cough syrup to give it a try......
Sorry if this rambles typing on my phone before bed. Maybe someone else has more experience with this specific combo med.
Posted by Scout2020 on December 9, 2014, at 12:47:51
In reply to Re: Nuedexta, posted by PeterMartin on December 9, 2014, at 2:23:11
Thanks PeterMartin.
Nuedexta contains DXM and quinidine. Use for depression is off-label. Perhaps quinidine cancels out some of the spaciness of DXM (?).
Neudexta is purportedly a ketamin analogue - minus hallucinations. There are several on-going clinical trials for each for TRD.
Will take you up on your good advice and sample DXM first, but maybe there's a synergistic effect of the DXM/quinidine combo that I'll miss.
Focusing on NMDA receptors is my last resort.
Posted by rjlockhart37 on December 9, 2014, at 18:04:33
In reply to Re: Nuedexta, posted by Scout2020 on December 9, 2014, at 12:47:51
DXM [dexromorphan] is nasty to me.....alot of past friends i met for a while used to always "sippin cough syprup" the DXM and puesdoephedrine....
it is nasty stuff.....i've sipped on nyquil couple times, just because i saw other people did it, it nasty....the taste and the feeling.....
dextromorthphan increases serotonin, im not sure about it's psyics how it does it does but that is how it causes a change in some people....
good luck with this new medicine.....not sure it will be a success but we will see.....
Posted by phidippus on December 10, 2014, at 14:30:32
In reply to Nuedexta, posted by Scout2020 on December 8, 2014, at 19:52:56
Nuedexta is quinidine with dextromethorphan.
It does not have the same side effects as Ketamine-it has its own set of crappy side effects.
At normal doses:
body rash/itching (see below)
Nausea
Vomiting
Drowsiness
Dizziness
Constipation
Diarrhea
Sedation
Confusion
Nervousness
Closed-eye hallucinationAt doses three to 10 times the recommended therapeutic dose:
Increased energy
Increased confidence
Mild nausea
Restlessness
Insomnia
"Speeding"/talking fast
Feelings of increased strength
Enlargened pupils/glazed eyes (but not red)At dosages 15 to 75 times the recommended therapeutic dose:
Hallucinations
Dissociation
Vomiting
Blurred vision and/or double vision
Bloodshot eyes
Dilated pupils
Sweating
Fever
Bruxia
Hypotension
Hypertension
Tachycardia
Shallow respiration
Diarrhea
Urinary retention
Muscle spasms
Sedation
Euphoria
Paresthesia
Blackouts
Sight loss
Inability to focus eyes
Skin rashDextromethorphan is the stuff they put in cough syrup. You can get high on it. Over-the-counter preparations containing dextromethorphan have been used in manners inconsistent with their labeling, often as a recreational drug.At doses much higher than medically recommended, DXM and its major metabolite, dextrorphan, acts as an NMDA receptor antagonist, which produces effects similar to, yet distinct from, the dissociative hallucinogenic states created by other dissociative anaesthetics such as ketamine and phencyclidine. It may produce distortions of the visual field - feelings of dissociation, distorted bodily perception, and excitement, as well as a loss of sense of time. Some users report stimulant-like euphoria, particularly in response to music. Dextromethorphan usually provides its recreational effects in a non-linear fashion, so that they are experienced in significantly varied stages. These stages are commonly referred to as "plateaus"
I would not take this drug for its anti-depressant effects.
Eric
Posted by PeterMartin on February 26, 2015, at 11:26:36
In reply to Re: Nuedexta, posted by Scout2020 on December 9, 2014, at 12:47:51
Just wanted to follow up and say this medication is different than I thought due to the inhibited breakdown. Its effect shouldn't be the same as OTC dextromethorphan (robotussin). More in this reedit discussion here: http://www.reddit.com/r/pharmacy/comments/1w02xl/does_anyone_know_about_nuedexta_andor_the/
My dad just started on it (he's very I'll w dementia). Hard to tell what it's doing for him since he doesnt talk much and declining rapidly.
Just wanted to update that I was incorrect.
Crazy expensive though. He has insurance (saved him $700 something) and it was still $80 for a month supply :-/
This is the end of the thread.
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