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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Meltingpot on September 18, 2012, at 9:04:47
Hi,
I'm currently on 40mg of seroxat and 200mg of trimipramine. I am feeling incredibly drowsy all of the time. Has anyone else been on this combination and is the drowsiness likely to go away?
Denise
Posted by SLS on September 18, 2012, at 10:11:50
In reply to Seroxat and trimipramine drowsiness, posted by Meltingpot on September 18, 2012, at 9:04:47
Because there is a pharmacokinetic interaction between these drugs, you must take only 1/2 the dosage of TCA normally used when combined with Seroxat. This might be true of trimipramine as well. If this interaction has not been addressed by your doctor, you will need to have a conversation with him about this. You don't want to become toxic on trimipramine. You should probably start with 25 mg/day and move to 50 - 75 mg/day.
- Scott
Posted by SLS on September 18, 2012, at 10:13:36
In reply to Seroxat and trimipramine drowsiness -To high!!! » Meltingpot, posted by SLS on September 18, 2012, at 10:11:50
Paroxetine increases serum trimipramine concentration. A report of two cases:
http://onlinelibrary.wiley.com/doi/10.1002/hup.470100415/abstract
- Scott
Posted by Phillipa on September 18, 2012, at 11:10:58
In reply to Re: Seroxat and trimipramine drowsiness -To high!!!, posted by SLS on September 18, 2012, at 10:13:36
Sounds like a med similar to luvox Phillipa
Posted by jono_in_adelaide on September 18, 2012, at 18:50:05
In reply to Seroxat and trimipramine drowsiness, posted by Meltingpot on September 18, 2012, at 9:04:47
Trimipramine is extremely sedating, so i think some drowsiness is inevitable with it, but the others are right, paroxetine slwos down its metabolism, and so you need to either change your SSRI (to sertaline or citralopam) or reduce the trimipramine
Posted by Meltingpot on November 18, 2012, at 13:43:21
In reply to Re: Seroxat and trimipramine drowsiness -To high!!!, posted by SLS on September 18, 2012, at 10:13:36
Hi Scott,
Thanks for your advice and the information, I'm grateful I have people like you to turn to for advice as I don't seem to have much joy with my local Doctor. The Doctor prescribing the drugs is quite a way from me so I don't get to see him often and I don't like to keep badgering them.
You've been really good over the years. When I called you "sweet", sorry that must have sounded a really condescending. what I meant is that you always seem to have time for other people and their problems in spite of your own. I also admire the methodical, rational way you go about evaluating the medication you take and it's affect on you.
Sorry for not getting back earlier but sleeping a lot (when not working) and then I came off everything and felt really bad, suicidal. Now on Zeroxat and Trazodone which again was making me too drowsy (but not in the same way as the trimupramine, felt unsafe driving the car on trimipramine). I've reduced the trazadone to 50mg from 100mg which seems to be helping with the tiredness.
How are you feeling? Any closer to getting a job? I'm amazed that you are unable to work because cognitively you seem really on the ball.
Denise
Posted by Meltingpot on November 18, 2012, at 13:43:36
In reply to Re: Seroxat and trimipramine drowsiness -To high!!!, posted by SLS on September 18, 2012, at 10:13:36
Hi Scott,
Thanks for your advice and the information, I'm grateful I have people like you to turn to for advice as I don't seem to have much joy with my local Doctor. The Doctor prescribing the drugs is quite a way from me so I don't get to see him often and I don't like to keep badgering them.
You've been really good over the years. When I called you "sweet", sorry that must have sounded a really condescending. what I meant is that you always seem to have time for other people and their problems in spite of your own. I also admire the methodical, rational way you go about evaluating the medication you take and it's affect on you.
Sorry for not getting back earlier but sleeping a lot (when not working) and then I came off everything and felt really bad, suicidal. Now on Zeroxat and Trazodone which again was making me too drowsy (but not in the same way as the trimupramine, felt unsafe driving the car on trimipramine). I've reduced the trazadone to 50mg from 100mg which seems to be helping with the tiredness.
How are you feeling? Any closer to getting a job? I'm amazed that you are unable to work because cognitively you seem really on the ball.
Denise
Posted by Meltingpot on November 18, 2012, at 13:45:08
In reply to Re: Seroxat and trimipramine drowsiness, posted by jono_in_adelaide on September 18, 2012, at 18:50:05
Thanks for your advice.
Denise
This is the end of the thread.
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