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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Conundrum on September 23, 2010, at 13:37:58
Aplenzin is the new version of Wellbutrin. Wellbutrin is bupropion hydrochloride and Aplenzin is bupropion hydrobromide. Does anyone have any experience with this new formulation. Supposedly its wellbutrin xl without as many side effects, sort of like pristiq. Is it really as effective as wellbutrin or just another attempt at making money.
I've seen reviews to be good to be true on some forums that make me think the reviewers are pharmaceutical reps. Any regulars here tried it?
Posted by creepy on September 23, 2010, at 14:58:21
In reply to Aplenzin hope or hype?, posted by Conundrum on September 23, 2010, at 13:37:58
Same drug, just a different timed delivery mechanism.
I really dont think this will do anything different from wellbutrin.
It will probably work a little better and have a little less anxiety potential than some of the generics. Not worth the extra cost.
Posted by Bob12 on September 23, 2010, at 16:42:20
In reply to Aplenzin hope or hype?, posted by Conundrum on September 23, 2010, at 13:37:58
I am also interested in Aplenzin. I have wanted to try some form of Wellbutrin for a while , but have always worrieed about the side effects of increased anxiety and insomnia.
Has anyone tried Aplenzin and not had insomnia or increased anxiety?
thanks
Bob12
Posted by Phillipa on September 23, 2010, at 16:59:08
In reply to Re: Aplenzin hope or hype?, posted by Bob12 on September 23, 2010, at 16:42:20
Must be very new as just got notification of it yesterday. Regular anxiety was horrible so if same med how could it be any different? Phillipa
Posted by linkadge on September 23, 2010, at 17:22:00
In reply to Re: Aplenzin hope or hype?, posted by Phillipa on September 23, 2010, at 16:59:08
Pristiq and effexor are different drugs. Aplenzin is still wellbutrin. I don't know how side effects would be reduced. Seems like a marketing tactic.
Linkadge
Posted by Conundrum on September 23, 2010, at 17:59:34
In reply to Re: Aplenzin hope or hype?, posted by linkadge on September 23, 2010, at 17:22:00
You're right about pristiq. Supposedly the bromide salt makes bupropion less likely to cause siezures. So perhaps even a different method of delivery has important effects.
Posted by Phillipa on September 23, 2010, at 20:53:59
In reply to Re: Aplenzin hope or hype?, posted by linkadge on September 23, 2010, at 17:22:00
Not to hyjack but how are pristiq and effexor different thought one was just time release? Phillipa
Posted by linkadge on September 24, 2010, at 7:09:25
In reply to Re: Aplenzin hope or hype? » linkadge, posted by Phillipa on September 23, 2010, at 20:53:59
pristiq is a metabolite of effexor, the body would convert part of effexor to pristiq, but this depends on individual differences in effexor metabolism. Also, the parent drug (venlafaxine) has different properties than pristiq (desvenlafaxine)
Its like amitriptyline is converted to nortriptyline in the body, but nortriptyline has different properties than amitriptyline.
Taking amitriptyline will give you the effect of two drugs (amitriptyline plus nortriptyline as it is metabolised), but just taking nortriptyline you only get one drug.
Posted by Conundrum on September 24, 2010, at 7:59:16
In reply to Re: Aplenzin hope or hype? » linkadge, posted by Phillipa on September 23, 2010, at 20:53:59
One difference is that Effexor is a weak dopamine reuptake inhibitor. At higher doses this comes into play. Pristiq has almost zero impact on dopamine reuptake. So effexor should actually be more effective for some people.
Posted by Phillipa on September 24, 2010, at 20:13:30
In reply to Re: Aplenzin hope or hype? » Phillipa, posted by Conundrum on September 24, 2010, at 7:59:16
So does that make pristiqu more like an SSRI? And weaker than effexor? Less agitation better for thosse with anxiety. Thanks guys Phillipa
Posted by Conundrum on September 25, 2010, at 0:38:02
In reply to Re: Aplenzin hope or hype? » Conundrum, posted by Phillipa on September 24, 2010, at 20:13:30
Pristiq is still an SNRI it just doesn't have any effect on dopamine , but venlafaxine does.
Posted by Phillipa on September 25, 2010, at 19:18:11
In reply to Re: Aplenzin hope or hype? » Phillipa, posted by Conundrum on September 25, 2010, at 0:38:02
Thanks I did not know that. Phillipa
Posted by ed_uk2010 on September 28, 2010, at 17:35:35
In reply to Re: Aplenzin hope or hype? » Phillipa, posted by Conundrum on September 25, 2010, at 0:38:02
Aplenzin sounds like pure marketing hype to me. I would not anticipate any advantages over Wellbutrin Xl whatsoever.
Posted by jch on October 17, 2011, at 15:56:13
In reply to Aplenzin hope or hype?, posted by Conundrum on September 23, 2010, at 13:37:58
I don't know exactly how the HBr and the HCl effect the buprion but they are not interchangeable. Bromine is heavier than than chlorine, explains 358 =300
Bromine is much more reactive than chlorine.If you add them to the same substance you will 2 very different products i.e.
ethene+HCl = Ethyl Chloride, used in the production of TNT, an anti-knock additive
a mild anesthetic, a narcotic popperethene+HBr = bromoethane
a pesticideThe difference in seizure frequency, intensity,length, and permanent brain damage is already been demonstrated. Aplenzin in this respect is demonstrably superior.
I have been taking 358mgs of Aplenzin for 3 weeks and have experienced only one side effect, my tinnutus is of a higher pitch.
Posted by Conundrum on October 18, 2011, at 4:55:26
In reply to Re: Aplenzin hope or hype?, posted by jch on October 17, 2011, at 15:56:13
> I don't know exactly how the HBr and the HCl effect the buprion but they are not interchangeable. Bromine is heavier than than chlorine, explains 358 =300
> Bromine is much more reactive than chlorine.
>
> If you add them to the same substance you will 2 very different products i.e.
>
> ethene+HCl = Ethyl Chloride, used in the production of TNT, an anti-knock additive
> a mild anesthetic, a narcotic popper
>
> ethene+HBr = bromoethane
> a pesticide
>
> The difference in seizure frequency, intensity,length, and permanent brain damage is already been demonstrated. Aplenzin in this respect is demonstrably superior.
>
> I have been taking 358mgs of Aplenzin for 3 weeks and have experienced only one side effect, my tinnutus is of a higher pitch.Wow that was great info. I also had trouble with tinnitus on Wellbutrin. It was pretty bad.
This is the end of the thread.
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