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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by huxley on September 18, 2010, at 19:48:18
A question for you scientists out there.
If I disolve a 2.5mg tablet of Zyprexa in 100 ml of water will it be evenly dispersed?So will 50ml contain 1.25mg of zyprexa?
Posted by Maxime on September 19, 2010, at 0:08:26
In reply to Disolving pills in water question., posted by huxley on September 18, 2010, at 19:48:18
Perhaps you should ask your pharmacist. Or maybe ed_uk will post and have the answer for you.
Posted by Maxime on September 19, 2010, at 0:09:48
In reply to Disolving pills in water question., posted by huxley on September 18, 2010, at 19:48:18
Also, have you tried the Zydis form of Zyprexa? It melts in your mouth.
Posted by ed_uk2010 on September 19, 2010, at 8:43:46
In reply to Disolving pills in water question., posted by huxley on September 18, 2010, at 19:48:18
> A question for you scientists out there.
> If I disolve a 2.5mg tablet of Zyprexa in 100 ml of water will it be evenly dispersed?
>
> So will 50ml contain 1.25mg of zyprexa?According to the European Medicines Agency...
'Olanzapine is practically insoluble in water, however it has been demonstrated by appropriate solubility studies that olanzapine even in the 20mg tablets - highest strength - was completely soluble in 250ml of a range of media.'
Based on this (not very detailed) information, I would assume that you could easily dissolve up to 8mg of olanzapine in 100ml of water. You could probably dissolve more than 8mg but I don't know how much more.
So yes, 2.5mg of olanzapine should be evenly dispersed in 100ml of water, although some of the tablet ingredients may sink to the bottom. I do not know how quickly a tablet would disperse - probably depends on how much you poke it and stir it! The Zydis tabs probably disperse much more quickly than the standard tablets.
>So will 50ml contain 1.25mg of zyprexa?
It should do once dispersion is complete, but I do not know how long the other 50ml would be stable for. You should probably take the 50ml immediately after dispersion appears to be complete and then dispose of the other 50ml.
None of this should be taken as medical advice.
Posted by ed_uk2010 on September 19, 2010, at 8:51:57
In reply to Re: Disolving pills in water question. » huxley, posted by Maxime on September 19, 2010, at 0:09:48
> Also, have you tried the Zydis form of Zyprexa? It melts in your mouth.
The Zydis tablets can also be dispersed in water. They will disperse much more readily than the standard tablets, but you still need quite a lot of water to produce an even dispersion because olanzapine is quite insoluble in water.
Unfortunately, the lowest strength of Zydis is 5mg.
Posted by bleauberry on September 19, 2010, at 9:55:10
In reply to Disolving pills in water question., posted by huxley on September 18, 2010, at 19:48:18
I have experimented with this method using various meds. None dissolved well in water or juice. However, if the particles are small enough (crush the pills to powder before putting in water) you can shake it up good before taking your measured dose. The particles are fairly evenly distributed throughout, but you have to pour your dose quickly before they settle.
Some meds are available in liquid form. I don't know if zyprexa is.
Another option is to crush the pill to powder (using the back side of a spoon or butter knife), then visually make piles of your desired dose sizes. Not perfectly exact, but close enough for your puproses. The desired dose can be swallowed on a spoon of applesauce or whatever...something soft that can be immediately swallowed without any chewing.
Posted by ed_uk2010 on September 19, 2010, at 10:23:32
In reply to Re: Disolving pills in water question., posted by bleauberry on September 19, 2010, at 9:55:10
>I don't know if zyprexa is.
It isn't. A liquid form would be useful, but it might be difficult to formulate due to the poor solubility of olanzapine, so I don't think we'll ever see one marketed.
Posted by Phillipa on September 19, 2010, at 12:23:29
In reply to Re: Disolving pills in water question. » bleauberry, posted by ed_uk2010 on September 19, 2010, at 10:23:32
Can you just take pieces of the pills? Might not be exact but might just work. Phillipa ps I split pills all the time and know the sizes arent exact but I don't feel it makes that much difference.
Posted by huxley on September 20, 2010, at 1:10:22
In reply to Re: Disolving pills in water question. » huxley, posted by Maxime on September 19, 2010, at 0:09:48
Thanks people. I am going to give it a shot later in the week.
I am dropping 2mg (not of zyprexa of the table) a week so it's hard getting an accurate or semi accurate reading. The scales I have seem to be all over the place.
will let you know how it goes. I will know if it doesnt work because if it is slightly out I will get a minor withdrawal.
Posted by Zyprexa on September 21, 2010, at 15:18:44
In reply to Re: Disolving pills in water question., posted by huxley on September 20, 2010, at 1:10:22
I think the best thing to do is just cut the pill. Just be realy carefull, you need the pill to stay still while cutting. I do this all the time. Cut a 10mg in half to take 15mg. I use a pill spliter with rubber walls, to hold the pill. You have to be real carefull that the pill is perfectly strait in the cutter. If you cut uneven you can take a knife (pairing knife, sharp one) and cut off little bit to make even. As long as you don't cut more than a week at a time you should not get any problems with it exposed to the air.
I have read on the perscribing info that zyprexa is not water soluable. So would not trust mixing it in water. I imagin it would sink to the bottom. I have never tried this so don't realy know.
Posted by chumbawumba on September 29, 2010, at 16:34:55
In reply to Re: Disolving pills in water question., posted by Zyprexa on September 21, 2010, at 15:18:44
I've done the water dissolve trick. Check the solubility of any medication in the physicians prescribing information. Heat the water a little to help it dissolve. Even if it's not soluble in water you can just shake it up and quickly take a dose of the resulting suspension. Most meds have talc and other binders in the tablet that will not dissolve so don't be suprized by some powder settling out.
This is the end of the thread.
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