Posted by ed_uk2010 on September 19, 2010, at 8:43:46
In reply to Disolving pills in water question., posted by huxley on September 18, 2010, at 19:48:18
> A question for you scientists out there.
> If I disolve a 2.5mg tablet of Zyprexa in 100 ml of water will it be evenly dispersed?
>
> So will 50ml contain 1.25mg of zyprexa?According to the European Medicines Agency...
'Olanzapine is practically insoluble in water, however it has been demonstrated by appropriate solubility studies that olanzapine even in the 20mg tablets - highest strength - was completely soluble in 250ml of a range of media.'
Based on this (not very detailed) information, I would assume that you could easily dissolve up to 8mg of olanzapine in 100ml of water. You could probably dissolve more than 8mg but I don't know how much more.
So yes, 2.5mg of olanzapine should be evenly dispersed in 100ml of water, although some of the tablet ingredients may sink to the bottom. I do not know how quickly a tablet would disperse - probably depends on how much you poke it and stir it! The Zydis tabs probably disperse much more quickly than the standard tablets.
>So will 50ml contain 1.25mg of zyprexa?
It should do once dispersion is complete, but I do not know how long the other 50ml would be stable for. You should probably take the 50ml immediately after dispersion appears to be complete and then dispose of the other 50ml.
None of this should be taken as medical advice.
poster:ed_uk2010
thread:962932
URL: http://www.dr-bob.org/babble/20100917/msgs/963003.html