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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 52 to 76 of 76. Go back in thread:
Posted by SLS on April 24, 2006, at 8:43:50
In reply to Re: Another drug failure » SLS, posted by scatterbrained on April 24, 2006, at 2:20:03
> You strike me as lucid enough to respond to it because you are able to work.
I wish I were. I haven't worked since April 15, 1990. If I can get 50% better, I probably could.
I've never seen a CBT workbook, but I use CBT tools in my day to day life. I have to recognize and "undo" the automatic thoughts that depression produces. Depression taints perceptions and interpretations. It is an unending task to prevent them from becoming internalized.
- Scott
Posted by SLS on April 24, 2006, at 8:49:27
In reply to Re: Another drug failure, posted by SLS on April 24, 2006, at 8:43:50
I have this nervous feeling in the pit of my stomach. I have reached the point where I feel I am doomed to never be free of this ubiquitous cognitive suppression and painful affective oppression. My thoughts turn towards autoeuthanasia.
- Scott
Posted by Crazy Horse on April 24, 2006, at 9:17:55
In reply to Re: Another drug failure, posted by SLS on April 24, 2006, at 8:49:27
> I have this nervous feeling in the pit of my stomach. I have reached the point where I feel I am doomed to never be free of this ubiquitous cognitive suppression and painful affective oppression. My thoughts turn towards autoeuthanasia.
>
>
> - Scott
>
>
I'm sorry that you have to feel this way. It's horrible, i've felt like that many times myself. Do you have and local physical support Scott? A wife, parents, siblings, friends, someone you can lean on to help you at this time? Have you considered being hospitalized? I Just don't think being alone is good.Monte
Posted by SLS on April 24, 2006, at 9:33:26
In reply to Re: Another drug failure » SLS, posted by Crazy Horse on April 24, 2006, at 9:17:55
> > I have this nervous feeling in the pit of my stomach. I have reached the point where I feel I am doomed to never be free of this ubiquitous cognitive suppression and painful affective oppression. My thoughts turn towards autoeuthanasia.
> I'm sorry that you have to feel this way. It's horrible, i've felt like that many times myself. Do you have and local physical support Scott? A wife, parents, siblings, friends, someone you can lean on to help you at this time? Have you considered being hospitalized? I Just don't think being alone is good.
I go to a clinical 2-3 times a week for psychological and emotional support. I almost don't want to be bothered going today, but I guess it would be good for me.
I still can't believe this stuff just stopped working for me. I thought that after two weeks of improvement, I would be home-free. My outlook was positive and optimistic. I was beginning to plan my future as a healthy adult. It all came crashing down on me last week.
- Scott
Posted by jparsell82 on April 24, 2006, at 9:45:21
In reply to Re: Another drug failure » Crazy Horse, posted by SLS on April 24, 2006, at 9:33:26
Have you tried adding a dopamine agonist? I found Trivastal to feel a lot better than Requip or Dostinex. Perhaps you could give Trivastal a try?
Posted by ed_uk on April 24, 2006, at 13:01:41
In reply to Re: Another drug failure, posted by SLS on April 24, 2006, at 8:49:27
Scott,
Are you going to try 450mg Wellbutrin? Perhaps you could decrease your nortriptyline first then increase the Wellbutrin?
Regards
Ed
Posted by SLS on April 24, 2006, at 14:52:25
In reply to Re: Another drug failure » SLS, posted by ed_uk on April 24, 2006, at 13:01:41
> Scott,
>
> Are you going to try 450mg Wellbutrin? Perhaps you could decrease your nortriptyline first then increase the Wellbutrin?That's not a bad idea. I see my doctor on Wednesday. I might skip tonight's dose of nortriptyline to see how I feel tomorrow. Wellbutrin is supposed to be only mild as an inhibitor of 2D6, but I guess it only takes a little to make a big difference.
Thanks.
- Scott
Posted by ed_uk on April 24, 2006, at 16:57:18
In reply to Re: Another drug failure » ed_uk, posted by SLS on April 24, 2006, at 14:52:25
Hi Scott
>That's not a bad idea.
Thank Zeugie :)
Perhaps you could decrease nortriptyline to 75mg as you increase Wellbutrin to 450mg?
Ed
Posted by Cairo on April 24, 2006, at 21:50:52
In reply to Another drug failure, posted by SLS on April 22, 2006, at 9:11:50
I agree that drug interactions might be a place to start:
http://www.healthyplace.com/COMMUNITIES/depression/treatment/antidepressants/lose_effectiveness.asp
http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=338Cairo
Posted by exquilter on April 24, 2006, at 23:38:49
In reply to Re: Another drug failure, posted by Cairo on April 24, 2006, at 21:50:52
Scott,
A consulting Pdoc I saw at the Mayo Clinic years ago reminded me that there are millions of permutations of drug combinations, and that some are bound to work for any given person. Please don't give up yet. Please remember that healing is not a linear process, and we are all hoping you will feel better soon.
Exquilter
Posted by zeugma on April 25, 2006, at 18:10:18
In reply to Re: Another drug failure, posted by exquilter on April 24, 2006, at 23:38:49
hi Scott, I have seen Wellbutrin-induced dysphoria at close proximity and also know that you once had a dysphoric reaction to it.
if the response is similar this time, then perhaps it is simply not a drug that agrees with you.
do you have a history of consistent responses to drugs (i.e., dysphoric vs. minor improvements)?
-z
Posted by SLS on April 26, 2006, at 6:56:53
In reply to Re: Another drug failure, posted by zeugma on April 25, 2006, at 18:10:18
Hi Z.
I experienced dysphoria with Wellbutrin on the several occasions I tried it in the past. This time was different, though. The initial dysphoria was mild and transient. I also experienced anxiety with it this time around that I had not in the past.
My response to the addition of Wellbutrin followed a pattern similar to those I've had with antidepressants in the past. Two to three weeks after starting an antidepressant, I begin to improve markedly. This will last for 3 days to a week. I then relapse. I cannot recapture the antidepressant effect regardless of dosage adjustments and length of trial. This has been going on since 1982.
My brain seems to be very efficient at maintaining an abnormal homeostasis.
- Scott
> hi Scott, I have seen Wellbutrin-induced dysphoria at close proximity and also know that you once had a dysphoric reaction to it.
>
> if the response is similar this time, then perhaps it is simply not a drug that agrees with you.
>
> do you have a history of consistent responses to drugs (i.e., dysphoric vs. minor improvements)?
Posted by denise1966 on April 26, 2006, at 16:20:19
In reply to Re: Another drug failure » ed_uk, posted by SLS on April 24, 2006, at 14:52:25
Scott,
Never say never, there's always non medication options like this DBS, that sounds really promising to me and the good thing about it is that if it's going to work it seems to work straight away.
I know that one day you'll post on this board with a triumphant note saying "ureka!"
Denise
Posted by zeugma on April 26, 2006, at 18:03:36
In reply to Re: Another drug failure » zeugma, posted by SLS on April 26, 2006, at 6:56:53
hi Scott,
it sounds incredibly frustrating, not to mention dispiriting, to go through that pattern again and again.
My brain seems to be very efficient at maintaining an abnormal homeostasis.>>
on the other hand, you are resilient, likely for the same reason.
have your pdocs ever discussed the implications of your pattern of response with you? Perhaps a researcher who specifically focused on patterns of response to antidepressants and related meds might have some useful clues, particularly since the pattern appears so strong (unfortunately).-z
Posted by lemon68 on April 26, 2006, at 19:18:21
In reply to Re: Another drug failure » linkadge, posted by SLS on April 23, 2006, at 7:35:35
> I would probably try agomelatine simply because it is different from anything I've yet tried.
>
Hi Scott - I just recently heard about this med, which sounds like a possible godsend to those of us with insomnia mitigating depression. do you know anything about it? I read that it is in trials in Europe. any info would be appreciated, thanx...
Posted by SLS on April 26, 2006, at 20:42:03
In reply to Re: Another drug failure » SLS, posted by zeugma on April 26, 2006, at 18:03:36
Thank you all for your wonderful support and great ideas.
I saw my doctor today. He did the obvious. I will be increasing my dosage of Wellbutrin to 450mg.
Eureka?
Possibly. I took the extra 150mg as soon as I walked out the door. Within a few hours, I began to feel better with a reduction in depression and anxiety. I have a good feeling about this.
Currently:
nortriptyline 100mg
Wellbutrin 450mg
Lamictal 150mg
Abilify 10mg
- Scott
Posted by Phillipa on April 26, 2006, at 21:30:11
In reply to Re: Another drug failure, posted by SLS on April 26, 2006, at 20:42:03
Scott fingers and toes crossed. Love Phillipa
Posted by SLS on April 27, 2006, at 7:58:44
In reply to Re: Another drug failure » SLS, posted by Phillipa on April 26, 2006, at 21:30:11
> Scott fingers and toes crossed. Love Phillipa
Thanks.
Me too.
:-)
- Scott
Posted by SLS on April 27, 2006, at 8:00:19
In reply to Re: Another drug failure » Phillipa, posted by SLS on April 27, 2006, at 7:58:44
I'm doing a little better today.
I'm almost afraid to hope anymore.
- Scott
Posted by ed_uk on April 27, 2006, at 16:22:12
In reply to Re: Another drug failure » Phillipa, posted by SLS on April 27, 2006, at 7:58:44
>>Scott fingers and toes crossed. Love Phillipa
>Thanks.
>Me too.
>:-)ME TOO!!!
Ed
Posted by patrickhh on April 29, 2006, at 20:23:42
In reply to Re: Another drug failure » zeugma, posted by SLS on April 26, 2006, at 6:56:53
> Hi Z.
>
> I experienced dysphoria with Wellbutrin on the several occasions I tried it in the past. This time was different, though. The initial dysphoria was mild and transient. I also experienced anxiety with it this time around that I had not in the past.
>
> My response to the addition of Wellbutrin followed a pattern similar to those I've had with antidepressants in the past. Two to three weeks after starting an antidepressant, I begin to improve markedly. This will last for 3 days to a week. I then relapse. I cannot recapture the antidepressant effect regardless of dosage adjustments and length of trial. This has been going on since 1982.
>
> My brain seems to be very efficient at maintaining an abnormal homeostasis.
>
>
> - Scott
>
>
The loss of response you explain sounds like a soft bipolar sign.
Posted by SLS on April 30, 2006, at 7:59:31
In reply to Re: Another drug failure, posted by patrickhh on April 29, 2006, at 20:23:42
> > My response to the addition of Wellbutrin followed a pattern similar to those I've had with antidepressants in the past. Two to three weeks after starting an antidepressant, I begin to improve markedly. This will last for 3 days to a week. I then relapse. I cannot recapture the antidepressant effect regardless of dosage adjustments and length of trial. This has been going on since 1982.
> The loss of response you explain sounds like a soft bipolar sign.
Yes. I was diagnosed at the NIH as having bipolar disorder. I become manic only in association with the use of medication. This has happened only a handful of times.
- Scott
Posted by SLS on April 30, 2006, at 8:05:11
In reply to Re: Another drug failure » patrickhh, posted by SLS on April 30, 2006, at 7:59:31
I was teased once again. I experienced an improvement upon raising the dosage of Wellbutrin to 450mg. This time it lasted for only 3 days. This is turning out to be one hell of an emotional rollercoaster ride. I can't say that I feel any residual benefit. I wish I could.
- Scott
> > > My response to the addition of Wellbutrin followed a pattern similar to those I've had with antidepressants in the past. Two to three weeks after starting an antidepressant, I begin to improve markedly. This will last for 3 days to a week. I then relapse. I cannot recapture the antidepressant effect regardless of dosage adjustments and length of trial. This has been going on since 1982.
Posted by Phillipa on April 30, 2006, at 19:56:34
In reply to Re: Another drug failure, posted by SLS on April 30, 2006, at 8:05:11
Scott I don't know what to say except I'm so sorry. Love Phillipa
Posted by TJO on May 2, 2006, at 5:23:06
In reply to Re: Another drug failure » SLS, posted by Phillipa on April 30, 2006, at 19:56:34
Ditto-I'm so sorry
Tam
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