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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Crazy Horse on April 17, 2006, at 9:31:05
Hi Scott,
I am currently on 150 mgs. of Parnate, mostly due to the fact that the lower doses evenually weren't working as well. I've always needed high dose everything, since aquiring this lovely illness.I've read some of your posts from the past advocating the benefits of high dose parnate, so if you feel well enough today could you please answer some of the questions below?
1. What are the advantages of high dose parnate vs. 60-80 mgs? What happens chemically when the dose is higher...i.e., 100 mgs or more?
2. Is 150 mgs about the max? Are there any advantages of going higher than this? I know it probably depends on the individual. By advantages i mean less afternoon fatigue, better more consistant mood, less problems with insomnia.
3. Do you have and articles/studies i could read concerning the advantages of high dose parnate.
Thank you Scott. I hope you are having a good day. :)
-Crazy Horse/Tyler
Posted by SLS on April 17, 2006, at 10:02:12
In reply to SCOTT, Questions about high dose Parnate, posted by Crazy Horse on April 17, 2006, at 9:31:05
Hi Tyler.
Chairman_MAO has more experience with high-dose Parnate therapy and might be better able to answer your questions.
Yes, people have gone higher than 150mg. I have seen people go as high as 200mg. I believe Chairman_MAO reported experiencing less insomnia along with less daytime fatigue and sleepiness at higher dosages.
One abstract on Medline describes that high dosage, but not low dosage, Parnate treatment resulted in a downregulation of 5-HT2 receptors. 5-HT2 antagonism is thought to have value when treating depression or the negative symptoms of schizophrenia.
- Scott-------------------------------------------
168: J Neural Transm Suppl 1994;41:127-34Comparisons of the actions of high and low doses of the MAO inhibitor
tranylcypromine on 5-HT2 binding sites in rat cortex.Goodnough DB, Baker GB
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Tranylcypromine (TCP) is a commercially available antidepressant drug, and
recent literature reports suggest that high doses of this drug may be
particularly effective in treating refractory depression. Down-regulation of
5-HT2 receptors in rat cortex is an effect produced after chronic administration
of several antidepressants, and we have conducted a chronic study comparing low-
and high-dose TCP in this regard. Male Sprague-Dawley rats were administered TCP
(0.5 or 2.5 mg/kg/day) or vehicle (distilled water) via Alzet minipumps
implanted subcutaneously in the dorsal thoracic area. Groups of rats were killed
4, 10 or 28 days after pump implantation and whole cortex was dissected out and
utilized for preparation of a membrane fraction. Binding studies were performed
with this fraction using 3H-ketanserin as the radioligand. Down-regulation
(decrease in Bmax) of the 5-HT2 binding site was observed in high-dose animals
after 10 and 28 days but not after 4 days. Low-dose TCP had no effect on 5-HT2
densities at any time interval. The affinity of 3H-ketanserin for the 5-HT2 site
was not affected by either dose at any time interval. These results suggest that
down-regulation of the 5-HT2 site may contribute to the efficacy of high-dose
TCP in the treatment of refractory depression.PMID: 7931218, UI: 95016589
Posted by Crazy Horse on April 17, 2006, at 11:07:07
In reply to Re: SCOTT, Questions about high dose Parnate, posted by SLS on April 17, 2006, at 10:02:12
Thanks Scott...:^)
Tyler
Posted by MARTY on April 17, 2006, at 16:15:05
In reply to Re: SCOTT, Questions about high dose Parnate, posted by SLS on April 17, 2006, at 10:02:12
Hi Scott --Doesn't downregulating 5-HT2 suppose to help with sexual side-effects of AD ?
Thank,
Marty
> Hi Tyler.
>
> Chairman_MAO has more experience with high-dose Parnate therapy and might be better able to answer your questions.
>
> Yes, people have gone higher than 150mg. I have seen people go as high as 200mg. I believe Chairman_MAO reported experiencing less insomnia along with less daytime fatigue and sleepiness at higher dosages.
>
> One abstract on Medline describes that high dosage, but not low dosage, Parnate treatment resulted in a downregulation of 5-HT2 receptors. 5-HT2 antagonism is thought to have value when treating depression or the negative symptoms of schizophrenia.
>
>
> - Scott
>
> -------------------------------------------
>
>
> 168: J Neural Transm Suppl 1994;41:127-34
>
> Comparisons of the actions of high and low doses of the MAO inhibitor
> tranylcypromine on 5-HT2 binding sites in rat cortex.
>
> Goodnough DB, Baker GB
>
> Department of Psychiatry, University of Alberta, Edmonton, Canada.
>
> Tranylcypromine (TCP) is a commercially available antidepressant drug, and
> recent literature reports suggest that high doses of this drug may be
> particularly effective in treating refractory depression. Down-regulation of
> 5-HT2 receptors in rat cortex is an effect produced after chronic administration
> of several antidepressants, and we have conducted a chronic study comparing low-
> and high-dose TCP in this regard. Male Sprague-Dawley rats were administered TCP
> (0.5 or 2.5 mg/kg/day) or vehicle (distilled water) via Alzet minipumps
> implanted subcutaneously in the dorsal thoracic area. Groups of rats were killed
> 4, 10 or 28 days after pump implantation and whole cortex was dissected out and
> utilized for preparation of a membrane fraction. Binding studies were performed
> with this fraction using 3H-ketanserin as the radioligand. Down-regulation
> (decrease in Bmax) of the 5-HT2 binding site was observed in high-dose animals
> after 10 and 28 days but not after 4 days. Low-dose TCP had no effect on 5-HT2
> densities at any time interval. The affinity of 3H-ketanserin for the 5-HT2 site
> was not affected by either dose at any time interval. These results suggest that
> down-regulation of the 5-HT2 site may contribute to the efficacy of high-dose
> TCP in the treatment of refractory depression.
>
> PMID: 7931218, UI: 95016589
>
>
>
Posted by Phillipa on April 17, 2006, at 21:10:49
In reply to Re: SCOTT, Questions about high dose Parnate » SLS, posted by Crazy Horse on April 17, 2006, at 11:07:07
Hummmm Isn't supposed to be Monte? Love Phillipa
Posted by Crazy Horse on April 17, 2006, at 22:25:51
In reply to Re: SCOTT, Questions about high dose Parnate » Crazy Horse, posted by Phillipa on April 17, 2006, at 21:10:49
> Hummmm Isn't supposed to be Monte? Love Phillipa
Yes, but some people still know me only as "Tyler"
Love, Monte
This is the end of the thread.
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