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Re: SCOTT, Questions about high dose Parnate

Posted by SLS on April 17, 2006, at 10:02:12

In reply to SCOTT, Questions about high dose Parnate, posted by Crazy Horse on April 17, 2006, at 9:31:05

Hi Tyler.

Chairman_MAO has more experience with high-dose Parnate therapy and might be better able to answer your questions.

Yes, people have gone higher than 150mg. I have seen people go as high as 200mg. I believe Chairman_MAO reported experiencing less insomnia along with less daytime fatigue and sleepiness at higher dosages.

One abstract on Medline describes that high dosage, but not low dosage, Parnate treatment resulted in a downregulation of 5-HT2 receptors. 5-HT2 antagonism is thought to have value when treating depression or the negative symptoms of schizophrenia.


- Scott

-------------------------------------------


168: J Neural Transm Suppl 1994;41:127-34

Comparisons of the actions of high and low doses of the MAO inhibitor
tranylcypromine on 5-HT2 binding sites in rat cortex.

Goodnough DB, Baker GB

Department of Psychiatry, University of Alberta, Edmonton, Canada.

Tranylcypromine (TCP) is a commercially available antidepressant drug, and
recent literature reports suggest that high doses of this drug may be
particularly effective in treating refractory depression. Down-regulation of
5-HT2 receptors in rat cortex is an effect produced after chronic administration
of several antidepressants, and we have conducted a chronic study comparing low-
and high-dose TCP in this regard. Male Sprague-Dawley rats were administered TCP
(0.5 or 2.5 mg/kg/day) or vehicle (distilled water) via Alzet minipumps
implanted subcutaneously in the dorsal thoracic area. Groups of rats were killed
4, 10 or 28 days after pump implantation and whole cortex was dissected out and
utilized for preparation of a membrane fraction. Binding studies were performed
with this fraction using 3H-ketanserin as the radioligand. Down-regulation
(decrease in Bmax) of the 5-HT2 binding site was observed in high-dose animals
after 10 and 28 days but not after 4 days. Low-dose TCP had no effect on 5-HT2
densities at any time interval. The affinity of 3H-ketanserin for the 5-HT2 site
was not affected by either dose at any time interval. These results suggest that
down-regulation of the 5-HT2 site may contribute to the efficacy of high-dose
TCP in the treatment of refractory depression.

PMID: 7931218, UI: 95016589


 

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