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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Chairman_MAO on September 22, 2005, at 11:08:54
I have looked into synthesizing this drug, which is the GABA-T inhibiting metabolite of phenelzine. It is ludicrously cheap and easy to synth using chloroform, hydrazine, etc.
If I could get a synth done, would anyone be interested in purchasing this for research purposes?
Posted by djmmm on September 22, 2005, at 14:59:01
In reply to Phenylethylidenehydrazine, posted by Chairman_MAO on September 22, 2005, at 11:08:54
> I have looked into synthesizing this drug, which is the GABA-T inhibiting metabolite of phenelzine. It is ludicrously cheap and easy to synth using chloroform, hydrazine, etc.
>
> If I could get a synth done, would anyone be interested in purchasing this for research purposes?Why not get a Rx for Vigabatrin (Sabril)?
Posted by Chairman_MAO on September 22, 2005, at 15:21:25
In reply to Re: Phenylethylidenehydrazine, posted by djmmm on September 22, 2005, at 14:59:01
Umm, possible irreversible retinal damage? Also, PEH is way more potent (Paslawski 2001).
I can send you this in PDF if you babblemail me your email address.
Posted by Tom Twilight on September 22, 2005, at 16:42:44
In reply to Phenylethylidenehydrazine, posted by Chairman_MAO on September 22, 2005, at 11:08:54
> I have looked into synthesizing this drug, which is the GABA-T inhibiting metabolite of phenelzine. It is ludicrously cheap and easy to synth using chloroform, hydrazine, etc.
> If I could get a synth done, would anyone be interested in purchasing this for research purposes?Woy Chairman you certainly have some good ideas!
I don't really understand why this drug hasn't been researched in its own right anyway.
In the abstract I saw the researchers suggested that it merited further development.
Presumably Phenylethylidenehydrazine is what gives Nardil is powerful anti anxiety effect.xxx
PS. Chairman did you get my last babblemail?
I was wondering you new of any other top Pdocs in America, besides the ones you mentioned.
Posted by mworkman on September 22, 2005, at 18:23:32
In reply to Phenylethylidenehydrazine, posted by Chairman_MAO on September 22, 2005, at 11:08:54
how do you make it?
Posted by Chairman_MAO on September 22, 2005, at 20:23:12
In reply to Re: Phenylethylidenehydrazine, posted by mworkman on September 22, 2005, at 18:23:32
> how do you make it?
High yield, dirt cheap reagents, procedurally simple. My PhD organic chem friend told me that I could do it (I have no chemistry training) if I had basic lab equipment.
PLZ sulfate was obtained from xxx...
Posted by mworkman on September 22, 2005, at 23:21:34
In reply to This is how you make it » mworkman, posted by Chairman_MAO on September 22, 2005, at 20:23:12
Did your friend make it? Have you made it? Can you just order the chemicals from a vendor?
Posted by yxibow on September 23, 2005, at 0:42:23
In reply to This is how you make it » mworkman, posted by Chairman_MAO on September 22, 2005, at 20:23:12
> > how do you make it?
>
> High yield, dirt cheap reagents, procedurally simple. My PhD organic chem friend told me that I could do it (I have no chemistry training) if I had basic lab equipment.Um... I have some chemistry training and I wouldnt do the following.... Do you know how toxic the LD50 and explosive hydrazine is ? Its rocket fuel.
I've often thought how interesting it would be to synthesize hydrazine on its own (its not too difficult) but this is something for fume hoods, face shields, and chemical respirators. And chloroform, good heavens, ventilation is a must.
"In vacuo" requires some more sophisticated lab equipment, including a vacuum source (typically a water aspirator in a lab unless you have a huge budget for a mechanical one).
Chemical abstracts, like these, while they seem simple in a paragraph, aren't neccessarily the easiest thing to do, and one should definately have a well ventilated lab setup.
I like chemistry, but think first before one acts. And I'd be very hesitant to ingest anything that comes out of such an experiment or any chemical lab. Tests have to be performed to determine there are no solvents left in the resultant, etc.
Tidings
Posted by Tom Twilight on September 23, 2005, at 4:13:38
In reply to Re: This is how you make it » Chairman_MAO, posted by yxibow on September 23, 2005, at 0:42:23
>Tests have to be performed to determine there are no solvents left in the resultant, etc.
Yes absolutly, even if the reaction has succeeded it should be tested for Hydrazine residue and Heavy metals
Posted by bigcat on September 23, 2005, at 14:07:42
In reply to Re: This is how you make it, posted by Tom Twilight on September 23, 2005, at 4:13:38
xxx "Red-tagging" medical research and hysteria is so consistently (and criminally) false anyway. I think, for me at least, that the greater danger would be NOT experimenting. If gangrene were a potential risk factor, I'd still have nothing to lose.
Posted by Dr. Bob on September 23, 2005, at 19:09:47
In reply to Phenylethylidenehydrazine, posted by Chairman_MAO on September 22, 2005, at 11:08:54
> would anyone be interested in purchasing this for research purposes?
Please do not offer medication directly to others here. Or explain how to produce medication yourself.
If you or others have questions about this or about posting policies, please see the FAQ:
http://www.dr-bob.org/babble/faq.html#illegal
Follow-ups regarding these issues should be redirected to Psycho-Babble Administration.
Thanks,
Bob
This is the end of the thread.
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