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Dr. Bob is Robert Hsiung, MD,
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Posted by neo on November 4, 2004, at 19:12:24
HI!
Wich are the most important difference between Benzo used for insomnia and the new cathegory of simil-benzo (zaleplon, zolpidem, brand Sonata or Ambien)?
They seems to act in the same way on the gaba receptors.
I've read that S-BDZ do not give withdrawal sympthoms nor tollerance or addiction. So you can use them till your sleep disorder persist.
Bdz are prescribed for 14-30 gg max use.
In my case zolpidem seems very similar in effect as bdz like triazolam.
Where is the difference between?
Thanx very much indeed for your share and help.
Neo ----- AFMAE (apologize for my awful English)
Posted by darkhorse on November 5, 2004, at 5:58:53
In reply to BDZ v/s SIMIL-BDZ(sonata,ambien): what difference?, posted by neo on November 4, 2004, at 19:12:24
I also took those Z medications + benzo hypnotics and I think it is only a market thing to try and sell them as different than benzos...but the truth is they are chemically different but work in the same area as benzos and lead to dependence and withdrawal in the long term....my prefered hypnotic med is Lorazepam.
Adam.
Posted by Larry Hoover on November 5, 2004, at 9:33:10
In reply to BDZ v/s SIMIL-BDZ(sonata,ambien): what difference?, posted by neo on November 4, 2004, at 19:12:24
> HI!
> Wich are the most important difference between Benzo used for insomnia and the new cathegory of simil-benzo (zaleplon, zolpidem, brand Sonata or Ambien)?
> They seems to act in the same way on the gaba receptors.What you're calling simil-benzo bind specifically to the BZD-1 receptor site. They're a little more specific in where they bind, is all.
> I've read that S-BDZ do not give withdrawal sympthoms nor tollerance or addiction. So you can use them till your sleep disorder persist.
There is actually little evidence that the hypnotic benzos lead to tolerance and addiction. There is some rebound effect on withdrawal, but that's not the same thing as tolerance and addiction.
> Bdz are prescribed for 14-30 gg max use.
> In my case zolpidem seems very similar in effect as bdz like triazolam.Triazolam is very short-acting. You might get more sustained effect from temazepam. There are case histories of it remaining efficacious for years. One case has been followed for 17 years.
> Where is the difference between?
> Thanx very much indeed for your share and help.
> Neo ----- AFMAE (apologize for my awful English)I think the differences between these classes of drugs are more of a marketing angle than a scientific fact.
Lar
Posted by King Vultan on November 5, 2004, at 11:58:00
In reply to BDZ v/s SIMIL-BDZ(sonata,ambien): what difference?, posted by neo on November 4, 2004, at 19:12:24
As stated in "Essential Psychopharmacology", "Zaleplon (Sonata) and zolpidem (Ambien) act selectively at omega 1 benzodiazepine receptors involved in sedation, but not at omega 2 benzodiazepine receptors concentrated in brain areas regulating cognition, memory, and motor functioning. Thus, such agents should theoretically have less of the unwanted cognitive, memory, and motor side effects of the benzodiazepines that act on both omega 1 and omega 2 receptors."
I think that's right, but IMO, Ambien and Sonata are less than ideal sleep drugs because their extremely short half lives can be a problem for some people who wake up after four or five hours and can't get back to sleep. They also do not seem quite as powerful as drugs like temazepam and triazolam and depending on one's insurance, can be very expensive.
Todd
Posted by neo on November 6, 2004, at 6:28:36
In reply to BDZ v/s SIMIL-BDZ(sonata,ambien): what difference?, posted by neo on November 4, 2004, at 19:12:24
This is the end of the thread.
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