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Re: BDZ v/s SIMIL-BDZ(sonata,ambien): what difference?

Posted by King Vultan on November 5, 2004, at 11:58:00

In reply to BDZ v/s SIMIL-BDZ(sonata,ambien): what difference?, posted by neo on November 4, 2004, at 19:12:24

As stated in "Essential Psychopharmacology", "Zaleplon (Sonata) and zolpidem (Ambien) act selectively at omega 1 benzodiazepine receptors involved in sedation, but not at omega 2 benzodiazepine receptors concentrated in brain areas regulating cognition, memory, and motor functioning. Thus, such agents should theoretically have less of the unwanted cognitive, memory, and motor side effects of the benzodiazepines that act on both omega 1 and omega 2 receptors."

I think that's right, but IMO, Ambien and Sonata are less than ideal sleep drugs because their extremely short half lives can be a problem for some people who wake up after four or five hours and can't get back to sleep. They also do not seem quite as powerful as drugs like temazepam and triazolam and depending on one's insurance, can be very expensive.

Todd


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poster:King Vultan thread:411862
URL: http://www.dr-bob.org/babble/20041103/msgs/412133.html