Psycho-Babble Medication Thread 295325

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ZOLOFT - Dopamine???

Posted by SLS on January 1, 2004, at 10:01:18

How potent is Zoloft as a dopamine reuptake inhibitor? Compared to Effexor?

Thanks again.

- Scott

Re: ZOLOFT - Dopamine??? » SLS

Posted by rod on January 1, 2004, at 11:06:07

In reply to ZOLOFT - Dopamine???, posted by SLS on January 1, 2004, at 10:01:18

> How potent is Zoloft as a dopamine reuptake inhibitor? Compared to Effexor?
>
> Thanks again.
>
>
> - Scott

Im not sure...

look at the figure at http://www.preskorn.com/columns/9911.html

If I read it right, both Sertraline and Venlafaxine have an aprox. 100 fold increased affinity of Serotonin pumps vs. Dopamin pumps.

But my doctor told me that the net-effect of Sertraline overweights the effect of the blockade of the dopamine re-uptake pumps. And the net-effect of sertraline is increased *noradrenaline*, he said. I guess over some 5-ht receptors...

thats all I know

good luck with it!
Roland

Re: ZOLOFT - Dopamine???

Posted by scott-d-o on January 1, 2004, at 13:55:06

In reply to Re: ZOLOFT - Dopamine??? » SLS, posted by rod on January 1, 2004, at 11:06:07

Sertraline's ability to inhibit the DAT (dopamine transporter) is so weak in comparison to the SERT inhibition that after long term usage it has been shown to actually *increase* the activity of the DAT. This is why some people develop bruxism (teeth-grinding) as a result of SSRI usage.

If you are worried about dopamine you can always augment with buspirone (not a hard med to get due to virtually no abuse potential). Buspirone is a 5-HT1a agonist which causes release of dopamine and should also attenuate sertraline's ability to raise extracellular serotonin.

scott

Re: ZOLOFT - Dopamine???

Posted by zeugma on January 1, 2004, at 16:04:26

In reply to Re: ZOLOFT - Dopamine???, posted by scott-d-o on January 1, 2004, at 13:55:06

> Sertraline's ability to inhibit the DAT (dopamine transporter) is so weak in comparison to the SERT inhibition that after long term usage it has been shown to actually *increase* the activity of the DAT. This is why some people develop bruxism (teeth-grinding) as a result of SSRI usage.
>
> If you are worried about dopamine you can always augment with buspirone (not a hard med to get due to virtually no abuse potential). Buspirone is a 5-HT1a agonist which causes release of dopamine and should also attenuate sertraline's ability to raise extracellular serotonin.
>
> scott

My experience with buspirone was that it increased the 'mood-elevating' effects of my AD (nortriptyline) almost immediately. Of course this is contrary to what most people report about an up to 8-week latency period. It does help me with bruxism, even though mine isn't due to AD use, so it should be helpful with AD-induced bruxism as well. It has a mild calming effect.

The reason so many are dissatisfied with it, and have had to turn to benzodiazepines, is because it does virtually nothing for social anxiety or higher levels of general anxiety.

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