Re: ZOLOFT - Dopamine???

Posted by scott-d-o on January 1, 2004, at 13:55:06

In reply to Re: ZOLOFT - Dopamine??? » SLS, posted by rod on January 1, 2004, at 11:06:07

Sertraline's ability to inhibit the DAT (dopamine transporter) is so weak in comparison to the SERT inhibition that after long term usage it has been shown to actually *increase* the activity of the DAT. This is why some people develop bruxism (teeth-grinding) as a result of SSRI usage.
If you are worried about dopamine you can always augment with buspirone (not a hard med to get due to virtually no abuse potential). Buspirone is a 5-HT1a agonist which causes release of dopamine and should also attenuate sertraline's ability to raise extracellular serotonin.
scott

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ZOLOFT - Dopamine??? SLS 1/1/04
Re: ZOLOFT - Dopamine??? » SLS rod 1/1/04
Re: ZOLOFT - Dopamine??? scott-d-o 1/1/04
Re: ZOLOFT - Dopamine??? zeugma 1/1/04

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