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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by rod on May 24, 2003, at 11:10:12
I have a little question. I have come across
" ...induce, at microM concentrations, ... "
and I want to know if this is representative for therapheutic dosage. It is a german study with english abstract, so I suppose microM means micro mol, substance ammount in SI ("metric system"). But per what? This study reveals no further information about this. So maybe someone who is used in such matters can help me.
In particular they talk about amitriptyline.thanks in advance
Roland
Posted by Larry Hoover on May 24, 2003, at 15:54:18
In reply to Help needed. what is microM concentration, posted by rod on May 24, 2003, at 11:10:12
> I have a little question. I have come across
> " ...induce, at microM concentrations, ... "
> and I want to know if this is representative for therapheutic dosage. It is a german study with english abstract, so I suppose microM means micro mol, substance ammount in SI ("metric system"). But per what? This study reveals no further information about this. So maybe someone who is used in such matters can help me.
> In particular they talk about amitriptyline.
>
> thanks in advance
> RolandSorry, I missed this post until now.....
microM stands for microMolar (M = moles/litre), which is a concentration term. It's sort of like parts per million, but not really. Parts per million is on a mass basis, whereas microMolar is molecules in a given volume. One mole is 6.022 X 10^23, so one microM solution is 6.022 X 10^17 molecules per liter of solution.
Few drugs (none?)would reach microM concentrations under normal therapeutic use, as far as I know.
Lar
Posted by rod on May 25, 2003, at 8:04:22
In reply to Re: Help needed. what is microM concentration, posted by Larry Hoover on May 24, 2003, at 15:54:18
> microM stands for microMolar (M = moles/litre),
thanks, thats exactlay what I wanted to know.
> Few drugs (none?)would reach microM concentrations under normal therapeutic use, as far as I know.
>
> Lar
>you are right, even 300mg amitrip. is far away from this, if my calculation is right.
thanks again
Roland
Posted by Larry Hoover on May 25, 2003, at 9:02:38
In reply to Re: Help needed. what is microM concentration » Larry Hoover, posted by rod on May 25, 2003, at 8:04:22
> > microM stands for microMolar (M = moles/litre),
>
> thanks, thats exactlay what I wanted to know.Sorry about the other details....too much information. It wouldn't mean much to anyone who doesn't use those concepts routinely.
> > Few drugs (none?)would reach microM concentrations under normal therapeutic use, as far as I know.
> >
> > Lar
> >
>
> you are right, even 300mg amitrip. is far away from this, if my calculation is right.
>
> thanks again
> RolandYou're welcome. I looked at venlafaxine (Effexor), just to check my conclusion against available data, and the peak blood concentration doesn't hit 1 microM. I can't see how a compartment which draws from the blood (i.e. the CNS) could possibly obtain *higher* concentrations.
Lar
This is the end of the thread.
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