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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by JGm on April 12, 2002, at 13:25:56
Hi,
from the beginning of this week i'm on reboxetine 4 mg/d.
I'm a pure unipolar depressed, NO anxiuos, with negative simpthoms like anedonia, aenergia, aphatie, low mood....
I was on every kind of SSRi but i should quit them cause they increased my aenergie and gave me a lot of somnolence, dizzy, drowsy, ecc...
Rebox seem to give me, after few days, more energie and motivation, higher mood and no somnolence at all.
I feel more active even a little anxious, that for me is a good thing.
The only side effect i report are a little urinary disease (ritenction) and a little faster hartbeat.
For me have found a med that don't give me drowsyness, is a marvelous thing: on SSRI i was all the day in bed, can't work, study...always sleeping...
Now i feel active, even if more anxious, i can go out, drive.
Any experience in side effects of rebox?
They reduce in the following weeks?
Do you think i should increase the dosage to 8 mg/d (prescribed dosage)? What timing?
Any counsel?
I'll keep you informed about my trial!
Thank for your share.
bye
Posted by mat on April 12, 2002, at 17:33:58
In reply to REBOXETINE seems to work well for me!, posted by JGm on April 12, 2002, at 13:25:56
> Hi,
> from the beginning of this week i'm on reboxetine 4 mg/d.
> I'm a pure unipolar depressed, NO anxiuos, with negative simpthoms like anedonia, aenergia, aphatie, low mood....
> I was on every kind of SSRi but i should quit them cause they increased my aenergie and gave me a lot of somnolence, dizzy, drowsy, ecc...
> Rebox seem to give me, after few days, more energie and motivation, higher mood and no somnolence at all.
> I feel more active even a little anxious, that for me is a good thing.
> The only side effect i report are a little urinary disease (ritenction) and a little faster hartbeat.
> For me have found a med that don't give me drowsyness, is a marvelous thing: on SSRI i was all the day in bed, can't work, study...always sleeping...
> Now i feel active, even if more anxious, i can go out, drive.
> Any experience in side effects of rebox?
> They reduce in the following weeks?
> Do you think i should increase the dosage to 8 mg/d (prescribed dosage)? What timing?
> Any counsel?
> I'll keep you informed about my trial!
> Thank for your share.
> byehi,
its great to read that this drug is working so well, because i will start to take it the week after next(unipolar depression). i also am very interested in rebox because it is supposedly very good in improving social functioning, an aspect that would also be helpful for me.
i read a lot about side effects, but in general i'm not very sensitive-except sexual dysfunction. i'm really afraid that these will occur again (as with the ssri i tried-sertralin and paroxetin). if they occur with reboxetine, it's supposedly not lack of libido or ejaculatory delay,
but unability to get an erection (would be more problematic i think). do you have any problems in this respect?
mat
Posted by JohnX2 on April 12, 2002, at 22:28:33
In reply to REBOXETINE seems to work well for me!, posted by JGm on April 12, 2002, at 13:25:56
Posted by JGm on April 13, 2002, at 7:47:56
In reply to Re: REBOXETINE seems to work well for me!, posted by mat on April 12, 2002, at 17:33:58
Hi Mat,
I was on every kind of Ad (in particular SSRI and Tca) and i couldn't tolerate them cause 2 hevay side effects:
1) somnolence (drowsiness, dizziness)
2) sexual problem (lack of libido)
I think that sometimes lack of libido is worse than depression for your life's quality.
I'm a unipolar depressed NO anxiuos, so the sedative effect of AD was an extremely negative fact for me.
Reboxetine (here in Italy it's brand names are Davedax or Edronax) seems to be the only med that don't give such side effects cause it is absolutely non sedative and currently (after a week) it do not gave me reduction of libido.
I've noticed this right and side effects:
1) more active, higher attention, more mind-focused;
2) a mild sensation of diffused well being;
3) a little more sociability;
4) fresh skin sensation (face, hands, foots).
Side effect, in order of severity:
1) insomnia (i take a little dbz at nite);
2) urinary difficulty (seems to reduce day by day);
3) little difficulty in erection;
4)Heartbeat, palpitation;
5)general sense of mild anxiousness, excitement (you can use a xlow dosage of bdz in the case);
It is too early to notice an eventual anti-depressive effect, but i think that rebox, as it is an activant, it shouldn't have effect on libido but only on erection (like you sayd).
I think that SSRi gave me lack of libido cause of theyr sedative profile.
If you need to know something else let me know, however i'll keep posted in the future days about my trial.
Bye
Posted by mat on April 13, 2002, at 9:07:58
In reply to Re: REBOXETINE seems to work well for me! » mat, posted by JGm on April 13, 2002, at 7:47:56
> Hi Mat,
> I was on every kind of Ad (in particular SSRI and Tca) and i couldn't tolerate them cause 2 hevay side effects:
> 1) somnolence (drowsiness, dizziness)
> 2) sexual problem (lack of libido)
> I think that sometimes lack of libido is worse than depression for your life's quality.
> I'm a unipolar depressed NO anxiuos, so the sedative effect of AD was an extremely negative fact for me.
> Reboxetine (here in Italy it's brand names are Davedax or Edronax) seems to be the only med that don't give such side effects cause it is absolutely non sedative and currently (after a week) it do not gave me reduction of libido.
> I've noticed this right and side effects:
> 1) more active, higher attention, more mind-focused;
> 2) a mild sensation of diffused well being;
> 3) a little more sociability;
> 4) fresh skin sensation (face, hands, foots).
> Side effect, in order of severity:
> 1) insomnia (i take a little dbz at nite);
> 2) urinary difficulty (seems to reduce day by day);
> 3) little difficulty in erection;
> 4)Heartbeat, palpitation;
> 5)general sense of mild anxiousness, excitement (you can use a xlow dosage of bdz in the case);
> It is too early to notice an eventual anti-depressive effect, but i think that rebox, as it is an activant, it shouldn't have effect on libido but only on erection (like you sayd).
> I think that SSRi gave me lack of libido cause of theyr sedative profile.
> If you need to know something else let me know, however i'll keep posted in the future days about my trial.
> Byehi-
that's all very encouraging. i hope i will react in a similar way to reboxetin. my last trial (with milnacipran) was a desaster, my depression worsened i had to stop it after only about 4 weeks. at the moment i take no drugs at all. i think my depressive symptoms are very similar to yours-lack of energy etc. but interestingly, the ssri's i took had the opposite effect on my energy-level than on yours, they really kicked me out of bed. but unfortunately-the sexual side-effects.
but i do have another question: what do you mean with "urinary difficulty"? sounds like a stupid question (i know), but i would really want to know what that exactly is-because it is supposedly one of the more common side-effects.
(i hope my questions are not too unpleasant for you)thanks for your infos
mat
Posted by JGm on April 13, 2002, at 11:49:28
In reply to Re: REBOXETINE seems to work well for me!, posted by mat on April 13, 2002, at 9:07:58
Hi Mat, don't worry!
Urinary problems are in particular:
Hesitation (you have to wait more than ususal)
Little smart during urination;
More frequent stimulus to urinate.
They are NOT severe, and they faded during the week. I think they will increase again when i'll go up dosage, but i'm sure they'll fade again in another few days.
I've found out a scientific text that confirm our supposition that rebox do not interact with sexual function. It seems to be due rebox is a pure norandrenergic compound, and has not andrenergic, colinergic and istaminergic activity (in difference to SSRI).
Moreover, as you can read in the text that follow, sexual diseases seems to be due to the increase of serotonine (ssri effect).
Besides i signalize this link to an italian reserch on rebox (in Italy rebox is greatly used).
You can translate it using an online-translator:http://sopsi.archicoop.it/rivista/1999/vol5-3/marazzit.htm
Let me know something about your trial!
Bye
From
Clinical Psychiatry News
FDA Deems Antidepressant Reboxetine 'Approvable'
Elizabeth Mechcatie, Senior Writer
[Clinical Psychiatry News 27(9):8, 1999. © 1999 International Medical News Group.]--------------------------------------------------------------------------------
The antidepressant reboxetine is now considered "approvable" and is likely to receive full Food and Drug Administration approval by the end of the year.
In late July, the FDA issued an "approvable letter" regarding reboxetine, a selective norepinephrine reuptake inhibitor, for the treatment of depression. Reboxetine has been available in Europe for over a year.
In controlled clinical trials, 70%-80% of people with depression receiving reboxetine improved significantly, similar to the range associated with selective serotonin reuptake inhibitors (SSRIs) and tricyclics, said Dr. Christopher Gallin, vice president of clinical research-CNS at Pharmacia & Upjohn, the manufacturer of the drug.Most of the studies have been short-term, 8-week studies.
In an interview, Dr. Gallin described reboxetine as a well-tolerated, safe compound, with fewer side effects than SSRIs.
He referred to data suggesting the drug has some "potential" advantages over SSRIs in particular populations. In a study comparing reboxetine to fluoxetine in patients with depression, those patients with severe depression did significantly better with reboxetine than with fluoxetine. The potential advantage in treating severe depression is "something we're extensively exploring at this time," he said.
There are also data from a trial that used a Social Adjustment Scale, which found that reboxetine was associated with significantly better results than fluoxetine, data that are "consistent with the hypothesis that by inhibiting the norepinephrine reuptake system, we are increasing people's interest, energy, and motivation," Dr. Gallin said.
The company is launching two large trials that will rigorously test this hypothesis further.
Dr. Jack Gorman, who has not been involved in clinical trials of reboxetine but is familiar with the data, considers this drug "extremely interesting."
"Since the tricyclic era, we have not really had a pure norepinephrine reuptake inhibitor, and this is better than the tricyclics because that's all it is. It doesn't have any anticholinergic side effects," said Dr. Gorman, the Lieber professor of psychiatry and vice chair of research in the department of psychiatry, Columbia University, New York.
He also expects that it should be fairly well tolerated and should not have sexual side effects "if what we believe causes sexual side effects is true." It is thought that sexual side effects are caused by increased serotonin activity in the pathway from the midbrain raphe region down the spinal cord, he said in an interview.
Dr. Gallin said that in clinical trials, the incidence of sexual side effects are above those associated with placebo but are low and that the incidence of impotence has been 2%.
Once approved, Pharmacia & Upjohn will promote the antidepressant with Janssen Pharmaceutica under the trade name Vestra in the United States. It is marketed as Edronax and Norebox in other countries where it is approved
Posted by ben on April 13, 2002, at 14:16:53
In reply to Re: REBOXETINE seems to work well for me!, posted by mat on April 12, 2002, at 17:33:58
hi mat
tried reboxetine twice and both times i got urinary probs and sexual side effects (impotence) as well as increased hard rate
so i went off itben
Posted by mat on April 14, 2002, at 7:08:32
In reply to Re: REBOXETINE seems to work well for me!, posted by ben on April 13, 2002, at 14:16:53
hi ben
what kind of sexual side-effects did you experience? the same as with the ssri you tried or where they different from them (again, i hope my questions are not too unpleasant, but i would really like to get every informations about these things before i start rebox).
my problem with the ssri (paroxetin and sertralin) where lack of libido and (on better days) unability to reach orgasm (very annoying).
also-does anybody have an explanation why enhancing noradrenergic neurotransmission leads to unability to get an erection? is it because noradrenaline makes the penile vessels contract and so prevents the corpora cavernosa to fill properly?
also-what is the biological basis for the sexual side-effects of serotonin-enhancing antidepressants. i just read that this is because enhanced activity of a serotonergic projection from the midbrain-raphe cells to the spinal cord. but-does anybody know what then happens? i really would like to know whats going on in my body while taking these meds.
thank's for infos
mat
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