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Opioids as a treatment of last resort - Metyrapone » JahL

Posted by SLS on July 10, 2005, at 22:32:47

In reply to Re: Opioids as a treatment of last resort. Dr Bob, posted by JahL on July 10, 2005, at 19:02:06

Hi Jamie.

One day at a time, right?

It really sucks.

I know.

I wish things were different.

Anyway...

How would you go about getting mifepristone? Would you need to enter a study?

One thing you might want to look into is metyrapone. Metyrapone is an antiglucocorticoid (anti-cortisol) drug that is currently prescribed in the UK for Cushings Disease and probably a few other hypercortisolemic states. I think it works by inhibiting the synthesis of cortisol via two different metabolic pathways. You can't get it in the US except as a test for cortisol and HPA function. If it doesn't work, perhaps it will give you enough of a partial or transient improvement to warrant further exploration of HPA stuff and further pursue mifepristone. Some studies of metyrapone combined it with ketoconazole.


- Scott

 

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