Posted by Larry Hoover on October 30, 2004, at 8:27:39
In reply to Re: dopamine oxidation » Larry Hoover, posted by raybakes on October 29, 2004, at 13:20:59
> Genetically i have high interleukin 1 and low glutathione (null gene), so I'm predisposed to autoimmune disease -
Ray, I'm very sorry. I didn't know that. I couldn't sleep last night, thinking about this. Please accept my apology. If you mentioned this before, I didn't see it, or don't recall it. All my opinions have been expressed under the assumptions that generally hold true. I didn't know you were the exception. How did you find out about the glutathione problem? And isn't IL-1 a response to oxidative stressors?
My intuitive response is for you to try and determine an exogenous antioxidant which has similar properties to that of glutathione. Frankly, I did not ever consider the ramifications of innate glutathione deficiency.
I'm immediately thinking of alphalipoic acid, and the polyphenolic antioxidants seen in e.g. pine bark or grape seed or berries. It would be lovely if someone ever put out a Venn diagram of the overlap between substrate activity of the different antioxidant systems. It would make this whole topic so very much easier to understand and to find appropriate interventions. I would need to look around a bit before I could come up with ideas not based on my intellectual intuition.
The other route would be immune modulation, as by omega-3 supplementation. Membrane disturbance induces degradation of phospholipids at the second position by phospholipase A2. You want an omega-3 fatty acid there, as much as is possible, to prevent inflammatory induction via cyclization of arachinodate to PGE-2.
> for me the autoxidation of catecholamines and serotonin is real, even with heavy intake of antioxdants - the research on quinones and kynurenine strikes a chord with me so I want to check it out and see if supporting that area helps my symptoms.
What antioxidants are you presently using?
> I'm thinking of getting a urine organic acid test to see if there are any high levels of toxic neurotransmitter metabolites - have you had your's checked out, or can you recommend any tests?
No. I'm fumbling in the dark, totally. I have trouble getting the simplest of blood or urine chemistries authorized, and I can't afford to pay for them myself. The vicious circle of poor health has got its grips in me. Poor health ---> can't work (much)---> can't afford assessment and treatment ---> poor health.
> Thanks, sorry about the dodgy metaphors!!
>
> RayAaaaccckkkk! Nothing we can't sort out.
Lar
poster:Larry Hoover
thread:404137
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/409089.html