Posted by Larry Hoover on October 11, 2003, at 10:04:55
In reply to B12- Hydroxycobalamin injections ..Lar, posted by tealady on October 11, 2003, at 0:27:02
> Hi Lar,
> Hoping to borrow your brain again, if you have some spare time ever?Now is a good time....
> I came acros this post last week in trying to work out my B12 reactions...
> "Injectable B12 is the main problem as it is stored in the liver and if one has altered CP450 enzymes, you can get toxicity( mainly skin problems ), but as for oral, there is no adverse effect.B12 is stored in the liver, period. I have no knowledge of any difference in rate of storage when comparing different routes of administration.
> B6 toxicity can cause a peripheral neuritis, but not B12, You are correct...it is a deficiency of B12 that presents as neuritis"
Embedded in that conclusion is the presumption that the B6 excess depletes local (peripheral) stores of B12, leading to side-effects (neuritis is one those).
> from Larrian in http://forums.about.com/ab-thyroid/messages?msg=39781.22
>
>
> I did a pubmed search on "hydroxycobalamin liver enzyme".....
>
> http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?http://www.jbc.org/cgi/pmidlookup?view=reprint&pmid=1657942 (full pdf atrticle)
>
>
> Krahenbuhl S, Chang M, Brass EP, Hoppel CL.
> Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria.
> J Biol Chem. 1991 Nov 5;266(31):20998-1003.
> PMID: 1657942 [PubMed - indexed for MEDLINE]
>
> The pubmed serach also comes up with 12 other studies..but I think this looks the most relevant..
>
> What is it saying please??As near as I can figure, their conclusion is that there is mid-term consequence from B12 supplementation, i.e. the (probably temporary....my interpretation) depletion of mineral/protein complexes which are associated with mitochondrial energy production. The mitochondria proliferate (short-term response), but they run out of a few key raw materials (mid-term response), which I would presume would be remedied by upregulated synthesis of the mineral/protein complexes (long-term response?).
Two things....we're not rats. Second, I don't see the findings as representing anything adverse, but rather, details of the process.
> I'm thinking perhaps I should not take any more injections?..just import the methylcobalmin from the US...the iherb postage went up from US$20 to US$40 !!!!(not for Canada though)
>
> Thanks , JanIf the injections are OK (your intuitive response), I don't see any particular need to switch sources.
You're welcome.
Lar
poster:Larry Hoover
thread:268166
URL: http://www.dr-bob.org/babble/alter/20031003/msgs/268307.html